Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 12/20 | 0.60 |
| ▸ | HDAC6 | Q9UBN7 | 10/20 | 0.60 |
| ▸ | HDAC8 | Q9BY41 | 8/20 | 0.60 |
| ▸ | HDAC3 | O15379 | 7/20 | 0.60 |
| ▸ | HDAC4 | P56524 | 7/20 | 0.60 |
| ▸ | HDAC7 | Q8WUI4 | 7/20 | 0.60 |
| ▸ | HDAC2 | Q92769 | 7/20 | 0.60 |
| ▸ | HDAC10 | Q969S8 | 7/20 | 0.60 |
| ▸ | HDAC9 | Q9UKV0 | 7/20 | 0.60 |
| ▸ | HDAC5 | Q9UQL6 | 7/20 | 0.60 |
| ▸ | HDAC11 | Q96DB2 | 6/20 | 0.60 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | CRHBP | P24387 | 1/20 | 0.36 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.36 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | APP | P05067 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14141462 | 1.00 | HDAC1 (0.60) | HDAC1HDAC6HDAC8HDAC3HDAC4 | |
| SCHEMBL17549781 | 0.88 | HDAC1 (0.77) | HDAC1HDAC6HDAC8HDAC3HDAC4 | |
| SCHEMBL25561421 | 0.85 | HDAC1 (0.51) | HDAC1HDAC6HDAC8HDAC3HDAC4 | |
| SCHEMBL14705471 | 0.84 | HDAC1 (0.52) | HDAC1HDAC6HDAC8HDAC3HDAC4 | |
| SCHEMBL8089729 | 0.82 | HDAC3 (0.40) | HDAC1HDAC6HDAC8HDAC3HDAC4 | |
| Trichostatin SCHEMBL675951 | 0.75 | HDAC1 (1.00) | HDAC1HDAC6HDAC8HDAC3HDAC4 | |
| Trichostatin SCHEMBL446806 | 0.75 | HDAC1 (1.00) | HDAC1HDAC6HDAC8HDAC3HDAC4 | |
| Trichostatin SCHEMBL16380793 | 0.75 | HDAC1 (1.00) | HDAC1HDAC6HDAC8HDAC3HDAC4 | |
| Trichostatin SCHEMBL446807 | 0.75 | HDAC1 (1.00) | HDAC1HDAC6HDAC8HDAC3HDAC4 | |
| Trichostatin SCHEMBL19886 | 0.75 | HDAC1 (1.00) | HDAC1HDAC6HDAC8HDAC3HDAC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007056135-A1 | METHOD OF TREATING CANCERS WITH SAHA AND PEMETREXED | MERCK & CO., INC. (US) | 2007-05-18 | — | — | WO | disclosed |
| WO-2007056162-A2 | METHODS OF TREATING CANCERS WITH SAHA, CARBOPLATIN, AND PACLITAXEL AND OTHER COMBINATION THERAPIES | MERCK & CO., INC. (US) | 2007-05-18 | — | — | WO | disclosed |
| WO-2007056244-A2 | METHODS OF USING SAHA AND ERLOTINIB FOR TREATING CANCER | MERCK & CO., INC. (US) | 2007-05-18 | — | — | WO | disclosed |
| WO-2005023179-A2 | COMBINATION METHODS OF TREATING CANCER | ATON PHARMA, INC. (US) | 2005-03-17 | — | — | WO | disclosed |
| WO-2005007091-A2 | HISTONE DEACETYLASE INHIBITORS AND METHODS OF USE THEREOF | GEORGETOWN UNIVERSITY (US) | 2005-01-27 | — | — | WO | disclosed |
| WO-2003088954-A1 | COMBINATION THERAPY FOR THE TREATMENT OF CANCER | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 2003-10-30 | — | — | WO | disclosed |