Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR1 | P21453 | 5/20 | 0.36 |
| ▸ | S1PR3 | Q99500 | 5/20 | 0.36 |
| ▸ | S1PR4 | O95977 | 2/20 | 0.36 |
| ▸ | S1PR5 | Q9H228 | 2/20 | 0.36 |
| ▸ | TAOK1 | Q7L7X3 | 3/20 | 0.36 |
| ▸ | TAOK3 | Q9H2K8 | 3/20 | 0.36 |
| ▸ | PPARG | P37231 | 1/20 | 0.35 |
| ▸ | PPARA | Q07869 | 1/20 | 0.35 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.35 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.35 |
| ▸ | THRA | P10827 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | CTSD | P07339 | 1/20 | 0.34 |
| ▸ | BACE1 | P56817 | 1/20 | 0.34 |
| ▸ | HTR2A | P28223 | 1/20 | 0.34 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.34 |
| ▸ | PRKCG | P05129 | 1/20 | 0.34 |
| ▸ | PRKCB | P05771 | 1/20 | 0.34 |
| ▸ | PRKCA | P17252 | 1/20 | 0.34 |
| ▸ | PRKCH | P24723 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2285235 | 0.87 | PPARA (0.40) | S1PR1S1PR3S1PR4S1PR5PPARG | |
| SCHEMBL14206102 | 0.86 | S1PR1 (0.42) | S1PR1S1PR3S1PR4S1PR5TAOK1 | |
| SCHEMBL1473439 | 0.84 | CTSD (0.41) | S1PR1S1PR3S1PR4S1PR5TAOK1 | |
| SCHEMBL12749385 | 0.82 | S1PR1 (0.50) | S1PR1S1PR3S1PR4S1PR5TAOK1 | |
| SCHEMBL2011162 | 0.82 | PPARA (0.42) | S1PR1S1PR3S1PR4S1PR5PPARG | |
| SCHEMBL2285244 | 0.80 | S1PR1 (0.37) | S1PR1S1PR3S1PR4S1PR5PPARG | |
| SCHEMBL2011165 | 0.75 | PRKCG (0.35) | S1PR1S1PR3S1PR4S1PR5PPARG | |
| SCHEMBL2805053 | 0.75 | PPARA (0.47) | S1PR1S1PR3S1PR4S1PR5PPARG | |
| SCHEMBL3844078 | 0.73 | THRA (0.40) | S1PR1S1PR3S1PR4S1PR5TAOK1 | |
| SCHEMBL1473437 | 0.71 | S1PR1 (0.52) | S1PR1S1PR3S1PR4S1PR5TAOK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7915315-B2 | Benzocycloheptyl analogs having sphingosine 1-phosphate receptor activity | UNIVERSITY OF VIRGINIA PATENT FOUNDATION (US) | 2011-03-29 | — | — | US | disclosed |
| US-7915315-B2 | Benzocycloheptyl analogs having sphingosine 1-phosphate receptor activity | UNIVERSITY OF VIRGINIA PATENT FOUNDATION (US) | 2011-03-29 | — | — | US | disclosed |
| US-20090253761-A1 | BENZOCYCLOHEPTYL ANALOGS HAVING SPHINGOSINE 1-PHOSPHATE RECEPTOR ACTIVITY | UNIVERSITY OF VIRGINIA PATENT FOUNDATION | 2009-10-08 | — | — | US | disclosed |
| US-20090253761-A1 | BENZOCYCLOHEPTYL ANALOGS HAVING SPHINGOSINE 1-PHOSPHATE RECEPTOR ACTIVITY | UNIVERSITY OF VIRGINIA PATENT FOUNDATION | 2009-10-08 | — | — | US | disclosed |
| EP-2097371-A2 | BENZOCYCLOHEPTYL ANALOGS HAVING SPHINGOSINE 1-PHOSPHATE RECEPTOR ACTIVITY | University Of Virginia Patent Foundation (US) | 2009-09-09 | — | — | EP | disclosed |
| WO-2008064337-A2 | BENZOCYCLOHEPTYL ANALOGS HAVING SPHINGOSINE 1-PHOSPHATE RECEPTOR ACTIVITY | UNIVERSITY OF VIRGINIA PATENT FOUNDATION (US) | 2008-05-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090253761-A1 | BENZOCYCLOHEPTYL ANALOGS HAVING SPHINGOSINE 1-PHOSPHATE RECEPTOR ACTIVITY | S1PR1, S1PR4, S1PR2 | S1PR1 1/4885S1PR3 4/4885S1PR4 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.