Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDC7 | O00311 | 10/20 | 0.51 |
| ▸ | DBF4 | Q9UBU7 | 2/20 | 0.51 |
| ▸ | RET | P07949 | 3/20 | 0.44 |
| ▸ | PDPK1 | O15530 | 3/20 | 0.42 |
| ▸ | IKBKE | Q14164 | 3/20 | 0.42 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.42 |
| ▸ | CDK2 | P24941 | 7/20 | 0.41 |
| ▸ | CDK9 | P50750 | 7/20 | 0.41 |
| ▸ | CCNT1 | O60563 | 4/20 | 0.41 |
| ▸ | CCNA2 | P20248 | 4/20 | 0.41 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.41 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.41 |
| ▸ | CDC42BPB | Q9Y5S2 | 1/20 | 0.41 |
| ▸ | DAPK3 | O43293 | 3/20 | 0.40 |
| ▸ | PRKD3 | O94806 | 3/20 | 0.40 |
| ▸ | PAK4 | O96013 | 3/20 | 0.40 |
| ▸ | PIM1 | P11309 | 3/20 | 0.40 |
| ▸ | PRKACA | P17612 | 3/20 | 0.40 |
| ▸ | FLT3 | P36888 | 3/20 | 0.40 |
| ▸ | CDK8 | P49336 | 3/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2534515 | 0.67 | CDC7 (1.00) | CDC7DBF4RETPDPK1IKBKE | |
| SCHEMBL4761178 | 0.67 | CDC7 (0.45) | CDC7DBF4RETCDK9CCNT1 | |
| SCHEMBL4761180 | 0.67 | CDC7 (0.45) | CDC7DBF4RETCDK9CCNT1 | |
| SCHEMBL5618155 | 0.65 | TGFBR1 (0.71) | CDC7PDPK1IKBKETGFBR1CDK2 | |
| SCHEMBL16719379 | 0.65 | TGFBR1 (0.57) | CDC7PDPK1IKBKETGFBR1CDK2 | |
| SCHEMBL12346310 | 0.65 | ROCK1 (0.50) | CDC7DBF4RETCDK9CCNT1 | |
| SCHEMBL5095241 | 0.62 | CDC7 (0.47) | CDC7DBF4RETCDK9CCNT1 | |
| SCHEMBL2009355 | 0.62 | CHRM2 (0.50) | CDC7DBF4RETPDPK1IKBKE | |
| SCHEMBL4719579 | 0.62 | CHRNB2 (0.57) | — | |
| SCHEMBL4881480 | 0.62 | CHRNB2 (0.57) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2559694-A2 | Azaindoles useful as inhibitors of Janus kinases | Vertex Pharmaceuticals, Inc. (US) | 2013-02-20 | — | — | EP | disclosed |