Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.41 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 4/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | AHR | P35869 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28842256 | 0.81 | POLB (0.41) | POLBMAPTNR4A2LMNAKMT2A | |
| SCHEMBL439576 | 0.81 | NR4A2 (0.54) | POLBMAPTNR4A2LMNAKMT2A | |
| SCHEMBL8686911 | 0.80 | LMNA (0.47) | POLBCYP1A2MAPTNR4A2LMNA | |
| SCHEMBL8436758 | 0.71 | KMT2A (0.42) | POLBMAPTLMNAKMT2AALDH1A1 | |
| SCHEMBL30592750 | 0.70 | KDM4E (0.44) | POLBCYP1A2MAPTLMNAKMT2A | |
| SCHEMBL26998831 | 0.70 | ALDH1A1 (0.38) | NR4A2ALDH1A1HPGDHTTAHR | |
| SCHEMBL13681181 | 0.68 | ALDH1A1 (0.40) | POLBMAPTLMNAKMT2AALDH1A1 | |
| SCHEMBL7696417 | 0.68 | KDM4E (0.39) | POLBCYP1A2MAPTLMNAKMT2A | |
| SCHEMBL31350703 | 0.68 | ALDH1A1 (0.44) | POLBCYP1A2MAPTLMNAKMT2A | |
| SCHEMBL5258862 | 0.68 | POLB (0.56) | POLBCYP1A2MAPTNR4A2CRHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013024028-A1 | COMPOUNDS AND COMPOSITIONS FOR TREATING PROTEINOPATHIES | INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) (FR) | 2013-02-21 | — | — | WO | disclosed |