Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.36 |
| ▸ | DRD2 | P14416 | 1/20 | 0.36 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.36 |
| ▸ | HTR2C | P28335 | 1/20 | 0.35 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.34 |
| ▸ | KDM1A | O60341 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.33 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.33 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.33 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.33 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.33 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.33 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17444517 | 0.92 | NOTUM (0.36) | SIGMAR1KDM1AKDM4EHCRTR1LMNA | |
| SCHEMBL27212886 | 0.80 | TSHR (0.36) | TSHRLMNA | |
| SCHEMBL29127985 | 0.79 | KDM4E (0.37) | OPRM1KDM1AKDM4EHCRTR1LMNA | |
| SCHEMBL8328802 | 0.78 | GNRHR (0.40) | SIGMAR1DRD2OPRM1HTR2CKDM1A | |
| SCHEMBL3144433 | 0.70 | KMT2A (0.47) | DRD2TSHRKDM4EHCRTR1LMNA | |
| SCHEMBL29506784 | 0.70 | KMT2A (0.47) | DRD2TSHRKDM4EHCRTR1LMNA | |
| Bromide SCHEMBL5405629 | 0.68 | KMT2A (0.46) | DRD2TSHRKDM4EHCRTR1LMNA | |
| Iodide SCHEMBL3430930 | 0.68 | KMT2A (0.46) | DRD2TSHRKDM4EHCRTR1LMNA | |
| Iodide SCHEMBL29450224 | 0.68 | KMT2A (0.46) | DRD2TSHRKDM4EHCRTR1LMNA | |
| Bromide SCHEMBL29525346 | 0.68 | KMT2A (0.46) | DRD2TSHRKDM4EHCRTR1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8383642-B2 | Spiropiperidine compounds | ELI LILLY AND COMPANY (US) | 2013-02-26 | — | — | US | disclosed |