Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | NAMPT | P43490 | 4/20 | 0.36 |
| ▸ | CASP3 | P42574 | 5/20 | 0.36 |
| ▸ | CASP7 | P55210 | 4/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | CASP1 | P29466 | 1/20 | 0.34 |
| ▸ | CASP6 | P55212 | 1/20 | 0.34 |
| ▸ | NPY5R | Q15761 | 4/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2835146 | 0.87 | NPY5R (0.33) | NAMPTCASP3CASP7CASP1CASP6 | |
| SCHEMBL2833846 | 0.86 | LMNA (0.39) | LMNANAMPTCASP3CASP7ALDH1A1 | |
| SCHEMBL2360725 | 0.85 | HTR7 (0.34) | CASP3CASP7CASP1CASP6NPY5R | |
| SCHEMBL2831136 | 0.85 | LMNA (0.42) | LMNANAMPTCASP3CASP7ALDH1A1 | |
| SCHEMBL2833661 | 0.85 | HTR7 (0.34) | CASP3CASP7CASP1CASP6NPY5R | |
| SCHEMBL2837024 | 0.83 | OPRM1 (0.33) | CASP3CASP7CASP1CASP6NPY5R | |
| SCHEMBL2834813 | 0.83 | LMNA (0.43) | LMNANAMPTCASP3CASP7ALDH1A1 | |
| SCHEMBL2835081 | 0.82 | HTR7 (0.32) | CASP3NPY5R | |
| SCHEMBL2836662 | 0.81 | HTR7 (0.34) | CASP3CASP7CASP1CASP6NPY5R | |
| SCHEMBL2839171 | 0.80 | LMNA (0.41) | LMNANAMPTCASP3CASP7ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2356101-B1 | PYRIMIDINE- AND TRIAZINE-SULFONAMIDE DERIVATIVES AS BRADYKININ B1 RECEPTOR (B1R) INHIBITORS FOR THE TREATMENT OF PAIN | GRUENENTHAL GMBH (DE) | 2013-02-27 | — | — | EP | claimed |