Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AR | P10275 | 2/20 | 0.48 |
| ▸ | DRD2 | P14416 | 14/20 | 0.48 |
| ▸ | HTR2A | P28223 | 12/20 | 0.48 |
| ▸ | DRD3 | P35462 | 12/20 | 0.48 |
| ▸ | HTR1A | P08908 | 7/20 | 0.48 |
| ▸ | DRD4 | P21917 | 3/20 | 0.46 |
| ▸ | HTR2C | P28335 | 3/20 | 0.46 |
| ▸ | HTR2B | P41595 | 3/20 | 0.46 |
| ▸ | TNKS | O95271 | 1/20 | 0.44 |
| ▸ | DRD1 | P21728 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14715692 | 0.92 | DRD2 (0.49) | DRD2HTR2ADRD3HTR1ADRD4 | |
| SCHEMBL14715677 | 0.90 | AR (0.52) | ARDRD2HTR2ADRD3HTR1A | |
| SCHEMBL14715599 | 0.88 | AR (0.51) | ARDRD2HTR2ADRD3HTR1A | |
| SCHEMBL14715628 | 0.88 | DRD2 (0.49) | DRD2HTR2ADRD3HTR1ADRD4 | |
| SCHEMBL3083219 | 0.88 | DRD3 (0.62) | DRD2HTR2ADRD3HTR1ADRD4 | |
| SCHEMBL14715630 | 0.85 | DRD2 (0.51) | ARDRD2HTR2ADRD3HTR1A | |
| SCHEMBL3073465 | 0.79 | DRD3 (0.64) | DRD2HTR2ADRD3HTR1ADRD4 | |
| SCHEMBL14715648 | 0.79 | DRD2 (0.44) | ARDRD2HTR2ADRD3HTR1A | |
| SCHEMBL14715723 | 0.79 | DRD2 (0.44) | ARDRD2HTR2ADRD3HTR1A | |
| SCHEMBL3086163 | 0.78 | DRD3 (0.59) | ARDRD2HTR2ADRD3HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2079693-B1 | ETHER DERIVATIVES DUAL MODULATORS OF THE 5-HT2A AND D3 RECEPTORS | HOFFMANN LA ROCHE (CH) | 2013-02-27 | — | — | EP | claimed |