Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.34 |
| ▸ | HRH1 | P35367 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7944302 | 0.64 | HRH3 (0.77) | HRH3CYP1A2MAPK1SMN1; SMN2SIGMAR1 | |
| SCHEMBL13962337 | 0.61 | HRH3 (0.81) | HRH3CYP1A2MAPK1SMN1; SMN2SIGMAR1 | |
| SCHEMBL433324 | 0.61 | HRH3 (0.81) | HRH3CYP1A2MAPK1SMN1; SMN2SIGMAR1 | |
| SCHEMBL23828672 | 0.61 | HRH3 (0.81) | HRH3CYP1A2MAPK1SMN1; SMN2SIGMAR1 | |
| SCHEMBL4519052 | 0.61 | HRH3 (0.81) | HRH3CYP1A2MAPK1SMN1; SMN2SIGMAR1 | |
| SCHEMBL1964444 | 0.61 | CHRM2 (0.50) | HRH3CYP1A2MAPK1SMN1; SMN2HRH1 | |
| SCHEMBL19257139 | 0.60 | HRH3 (0.61) | HRH3SIGMAR1HRH1LMNA | |
| SCHEMBL6946433 | 0.60 | HRH3 (0.55) | HRH3CYP1A2MAPK1SMN1; SMN2SIGMAR1 | |
| SCHEMBL5467402 | 0.60 | CYP1A2 (0.48) | HRH3CYP1A2SIGMAR1 | |
| SCHEMBL13606455 | 0.60 | MGLL (0.58) | HRH3MAPK1SMN1; SMN2HRH1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1836174-B2 | ARYL NITROGEN-CONTAINING BICYCLIC COMPOUNDS AND THEIR USE AS KINASE INHIBITORS | AMGEN INC (US) | 2019-10-02 | — | — | EP | disclosed |
| EP-1836174-B1 | ARYL NITROGEN-CONTAINING BICYCLIC COMPOUNDS AND THEIR USE AS KINASE INHIBITORS | AMGEN INC (US) | 2013-02-27 | — | — | EP | disclosed |