SCHEMBL14715796

SCHEMBL14715796

O=C(O)NC(CCc1ccccc1)N1CCN(C(Cc2ccccc2)C2=COCO2)CC1

nearest known ligand 0.36

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 3/20 0.35
KMT2A Q03164 3/20 0.35
CTSS P25774 1/20 0.35
TAS1R3 Q7RTX0 1/20 0.34
TAS1R1 Q7RTX1 1/20 0.34
SLC6A4 P31645 3/20 0.34
SLC6A2 P23975 2/20 0.34
CYP1A2 P05177 1/20 0.34
CYP3A4 P08684 1/20 0.34
CYP2D6 P10635 1/20 0.34
TSHR P16473 1/20 0.34
CYP2C19 P33261 1/20 0.34
SLC6A3 Q01959 1/20 0.34
ALDH1A1 P00352 3/20 0.34
CNR2 P34972 1/20 0.33
CTSL P07711 1/20 0.33
HTT P42858 2/20 0.33
MAPT P10636 2/20 0.33
POLB P06746 1/20 0.33
HPGD P15428 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2853081 0.80 CHRM1 (0.41) SLC6A4SLC6A2CYP1A2CYP3A4CYP2D6
SCHEMBL3591699 0.77 FAAH (0.50) TSHRCYP2C19MAPT
SCHEMBL3708454 0.76 CYP1A2 (0.40) MEN1KMT2ASLC6A4SLC6A2CYP1A2
Hydrochloric Acid SCHEMBL3605151 0.76 FAAH (0.49) TSHRCYP2C19MAPTPOLBSMN1; SMN2
SCHEMBL15961230 0.76 SIGMAR1 (0.52) KMT2ASLC6A4SLC6A2CYP1A2CYP2D6
SCHEMBL2316904 0.75 SIGMAR1 (0.47) MEN1KMT2ACYP1A2CYP3A4CYP2D6
SCHEMBL592971 0.74 SLC6A4 (0.61) SLC6A4SLC6A2CYP1A2CYP2D6CYP2C19
SCHEMBL217536 0.74 CYP1A2 (0.42) MEN1KMT2ASLC6A4SLC6A2CYP1A2
SCHEMBL2116312 0.71 ADRB1 (0.48)
SCHEMBL4084298 0.71 MAPK1 (0.46) MEN1KMT2ASLC6A4SLC6A2CYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2150550-B1 NOVEL CARBAMOYLOXY ARYL ALKAN ARYLPIPERAZINE COMPOUND, PHARMACEUTICAL COMPOSITIONS COMPRISING THE COMPOUND AND METHOD FOR TREATING PAIN, ANXIETY AND DEPRESSION BY ADMINISTERING THE COMPOUND SK BIOPHARMACEUTICALS CO LTD (KR) 2013-02-27 EP disclosed