SCHEMBL14715899

SCHEMBL14715899

O=C(Nc1ccc(NC(=O)c2cc(C(=O)Nc3ccc(NC(=O)c4ccccc4)cc3)cc(C(=O)Nc3ccc(NC(=O)c4ccccc4)cc3)c2)cc1)c1ccccc1

nearest known ligand 0.77

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PTPN1 P18031 2/20 0.77
NPC1 O15118 6/20 0.74
RAB9A P51151 6/20 0.74
KMT2A Q03164 3/20 0.74
MEN1 O00255 2/20 0.74
SIRT1 Q96EB6 2/20 0.74
KDM4E B2RXH2 1/20 0.74
POLB P06746 1/20 0.74
MAPT P10636 1/20 0.71
SMN1; SMN2 Q16637 1/20 0.71
KCNK3 O14649 1/20 0.70
KCNK9 Q9NPC2 1/20 0.70
CACNA1B Q00975 1/20 0.69
APBA1 Q02410 1/20 0.69
PRMT1 Q99873 1/20 0.67
FFAR1 O14842 1/20 0.67
PGR P06401 1/20 0.67
HDAC1 Q13547 1/20 0.67
HDAC2 Q92769 1/20 0.67
HDAC8 Q9BY41 1/20 0.67

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14715851 0.94 KMT2A (0.79) PTPN1NPC1RAB9AKMT2AMEN1
SCHEMBL126415 0.93 PTPN1 (0.87) PTPN1NPC1RAB9AKMT2AMEN1
SCHEMBL14715824 0.91 NPC1 (0.88) PTPN1NPC1RAB9AKMT2AMEN1
SCHEMBL18103163 0.91 NPC1 (0.88) PTPN1NPC1RAB9AKMT2AMEN1
SCHEMBL2911616 0.91 HDAC2 (0.71) PTPN1NPC1RAB9AKMT2AMEN1
SCHEMBL26953087 0.89 PTPN1 (0.88) PTPN1NPC1RAB9AKMT2AMEN1
SCHEMBL24202631 0.89 SIRT1 (0.83) PTPN1NPC1RAB9AKMT2AMEN1
N-Phenylbenzamide SCHEMBL31966 0.89 SIRT1 (0.83) PTPN1NPC1RAB9AKMT2AMEN1
N-Phenylbenzamide SCHEMBL5402750 0.89 SIRT1 (0.83) PTPN1NPC1RAB9AKMT2AMEN1
SCHEMBL7790555 0.88 PTPN1 (0.71) PTPN1NPC1RAB9AKMT2AMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 106 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9127142-B2 Low temperature injection molding of polyarylene sulfide compositions TICONA LLC (US) 2015-09-08 US claimed
US-9096794-B2 High flow liquid crystalline polymer composition TICONA LLC (US) 2015-08-04 US claimed
US-9080036-B2 Nucleating system for polyarylene sulfide compositions TICONA LLC (US) 2015-07-14 US claimed
US-9074133-B2 Thermotropic liquid crystalline polymer with improved low shear viscosity TICONA LLC (US) 2015-07-07 US claimed
US-9045685-B2 Cast molded parts formed from a liquid crystalline polymer TICONA LLC (US) 2015-06-02 US claimed
US-9005475-B2 Aromatic amide compound TICONA LLC (US) 2015-04-14 US claimed
US-20140350156-A1 Low Temperature Injection Molding of Polyarylene Sulfide Compositions TICONA LLC (US) 2014-11-27 US claimed
US-8852730-B2 Melt-extruded substrate for use in thermoformed articles TICONA LLC (US) 2014-10-07 US claimed
US-20140288221-A1 Aromatic Amide Compound TICONA LLC (US) 2014-09-25 US claimed
US-20140242385-A1 Liquid Crystalline Polymer Fibers TICONA LLC (US) 2014-08-28 US claimed
US-20130157033-A1 Nucleating System for Polyarylene Sulfide Compositions TICONA LLC (US) 2013-06-20 US claimed
US-20130155597-A1 Molded Part for a Portable Electronic Device TICONA LLC (US) 2013-06-20 US claimed
US-20130062558-A1 Cast Molded Parts Formed from a Liquid Crystalline Polymer TICONA LLC (US) 2013-03-14 US claimed
US-20130048908-A1 Heat-Resistant Liquid Crystalline Polymer Composition having a Low Melting Temperature TICONA LLC (US) 2013-02-28 US claimed
US-20130052446-A1 Melt-Extruded Substrate for Use in Thermoformed Articles TICONA LLC (US) 2013-02-28 US claimed
US-20130052447-A1 Liquid Crystalline Polymer Composition Containing a Fibrous Filler TICONA LLC (US) 2013-02-28 US claimed
US-20130053533-A1 Solid-State Polymerization of a Liquid Crystalline Polymer TICONA LLC (US) 2013-02-28 US claimed
US-20130048911-A1 Aromatic Amide Compound TICONA LLC (US) 2013-02-28 US claimed
US-20130048910-A1 Thermotropic Liquid Crystalline Polymer with Improved Low Shear Viscosity TICONA LLC (US) 2013-02-28 US claimed
US-20130048909-A1 High Flow Liquid Crystalline Polymer Composition TICONA LLC (US) 2013-02-28 US claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20140288221-A1 Aromatic Amide Compound H1-3, H1-0, H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16 PTPN1 2592/4885NPC1 405/4885RAB9A 2174/4885
US-20130048911-A1 Aromatic Amide Compound H1-3, H1-0, H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16 PTPN1 2592/4885NPC1 405/4885RAB9A 2174/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.