SCHEMBL14715912

SCHEMBL14715912

O=C(Nc1cccc(NC(=O)c2cc(C(=O)Nc3cccc(NC(=O)c4ccccc4)c3)cc(C(=O)Nc3cccc(NC(=O)c4ccccc4)c3)c2)c1)c1ccccc1

nearest known ligand 0.92

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
▸ KCNK3 O14649 10/20 0.92
▸ KCNK9 Q9NPC2 8/20 0.92
▸ MEN1 O00255 5/20 0.80
▸ KMT2A Q03164 5/20 0.80
▸ SIRT1 Q96EB6 1/20 0.79
▸ TP53 P04637 1/20 0.74
▸ POLB P06746 1/20 0.72
▸ NPC1 O15118 2/20 0.71
▸ RAB9A P51151 2/20 0.71
▸ HPGD P15428 1/20 0.71
▸ HDAC1 Q13547 1/20 0.68
▸ HDAC2 Q92769 1/20 0.68
▸ HDAC8 Q9BY41 1/20 0.68
▸ HDAC6 Q9UBN7 1/20 0.68
▸ ALDH1A1 P00352 1/20 0.68
▸ MAPT P10636 1/20 0.68
▸ LPAR3 Q9UBY5 1/20 0.68

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14715827 0.96 KCNK3 (0.92) KCNK3KCNK9MEN1KMT2ASIRT1
SCHEMBL2298254 0.96 KCNK3 (1.00) KCNK3KCNK9MEN1KMT2ASIRT1
SCHEMBL14715821 0.92 KCNK3 (0.85) KCNK3KCNK9MEN1KMT2ASIRT1
SCHEMBL18953533 0.90 KCNK3 (0.89) KCNK3KCNK9MEN1KMT2ASIRT1
SCHEMBL14715832 0.90 KCNK3 (0.88) KCNK3KCNK9MEN1KMT2ASIRT1
SCHEMBL19491390 0.89 SIRT1 (1.00) KCNK3KCNK9MEN1KMT2ASIRT1
SCHEMBL28031075 0.88 KCNK3 (0.77) KCNK3KCNK9MEN1KMT2ASIRT1
SCHEMBL15177198 0.88 KCNK3 (0.77) KCNK3KCNK9MEN1KMT2ASIRT1
SCHEMBL14715899 0.88 PTPN1 (0.77) KCNK3KCNK9MEN1KMT2ASIRT1
SCHEMBL8374911 0.88 HDAC1 (0.85) KCNK3KCNK9MEN1KMT2ASIRT1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 104 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9127142-B2 Low temperature injection molding of polyarylene sulfide compositions TICONA LLC (US) 2015-09-08 — — US claimed
US-9096794-B2 High flow liquid crystalline polymer composition TICONA LLC (US) 2015-08-04 — — US claimed
US-9080036-B2 Nucleating system for polyarylene sulfide compositions TICONA LLC (US) 2015-07-14 — — US claimed
US-9074133-B2 Thermotropic liquid crystalline polymer with improved low shear viscosity TICONA LLC (US) 2015-07-07 — — US claimed
US-9045685-B2 Cast molded parts formed from a liquid crystalline polymer TICONA LLC (US) 2015-06-02 — — US claimed
US-9005475-B2 Aromatic amide compound TICONA LLC (US) 2015-04-14 — — US claimed
US-20140350156-A1 Low Temperature Injection Molding of Polyarylene Sulfide Compositions TICONA LLC (US) 2014-11-27 — — US claimed
US-8852730-B2 Melt-extruded substrate for use in thermoformed articles TICONA LLC (US) 2014-10-07 — — US claimed
US-20140288221-A1 Aromatic Amide Compound TICONA LLC (US) 2014-09-25 — — US claimed
US-20140242385-A1 Liquid Crystalline Polymer Fibers TICONA LLC (US) 2014-08-28 — — US claimed
US-20130157033-A1 Nucleating System for Polyarylene Sulfide Compositions TICONA LLC (US) 2013-06-20 — — US claimed
US-20130155597-A1 Molded Part for a Portable Electronic Device TICONA LLC (US) 2013-06-20 — — US claimed
US-20130062558-A1 Cast Molded Parts Formed from a Liquid Crystalline Polymer TICONA LLC (US) 2013-03-14 — — US claimed
US-20130053533-A1 Solid-State Polymerization of a Liquid Crystalline Polymer TICONA LLC (US) 2013-02-28 — — US claimed
US-20130048908-A1 Heat-Resistant Liquid Crystalline Polymer Composition having a Low Melting Temperature TICONA LLC (US) 2013-02-28 — — US claimed
US-20130052447-A1 Liquid Crystalline Polymer Composition Containing a Fibrous Filler TICONA LLC (US) 2013-02-28 — — US claimed
US-20130052446-A1 Melt-Extruded Substrate for Use in Thermoformed Articles TICONA LLC (US) 2013-02-28 — — US claimed
US-20130048911-A1 Aromatic Amide Compound TICONA LLC (US) 2013-02-28 — — US claimed
US-20130048909-A1 High Flow Liquid Crystalline Polymer Composition TICONA LLC (US) 2013-02-28 — — US claimed
US-20130048910-A1 Thermotropic Liquid Crystalline Polymer with Improved Low Shear Viscosity TICONA LLC (US) 2013-02-28 — — US claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20140288221-A1 Aromatic Amide Compound H1-3, H1-0, H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16 KCNK3 1070/4885KCNK9 1626/4885MEN1 3383/4885
US-20130048911-A1 Aromatic Amide Compound H1-3, H1-0, H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16 KCNK3 1070/4885KCNK9 1626/4885MEN1 3383/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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