SCHEMBL14716708

SCHEMBL14716708

CCc1ccc(N=Nc2nc3nc(N)[nH]c(=O)c3[nH]2)cc1

nearest known ligand 0.47

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
PNP P00491 5/20 0.47
FGFR1 P11362 1/20 0.43
FGFR2 P21802 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14716575 0.82 FGFR1 (0.58) PNPFGFR1FGFR2
SCHEMBL14716514 0.82 FGFR1 (0.48) PNPFGFR1FGFR2
SCHEMBL14716709 0.80 TYMS (0.41) PNP
SCHEMBL12321218 0.80 TYMS (0.41) PNP
SCHEMBL1301998 0.71 PNP (0.68) PNPFGFR1FGFR2
SCHEMBL874735 0.70 PNP (0.66) PNPFGFR1FGFR2
SCHEMBL14716410 0.69 FGFR1 (0.46) PNPFGFR1FGFR2
8-Aminoguanine SCHEMBL21761 0.68 PNP (1.00) PNPFGFR1FGFR2
SCHEMBL3303807 0.68 PNP (0.77) PNPFGFR1FGFR2
SCHEMBL10339631 0.67 PNP (0.61) PNPFGFR1FGFR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9458515-B2 RNA including nucleoside compound, method for regulating amount of protein produced from the RNA, and nucleoside compound RIKEN (JP) 2016-10-04 US disclosed
US-20130052710-A1 RNA INCLUDING NUCLEOSIDE COMPOUND, METHOD FOR REGULATING AMOUNT OF PROTEIN PRODUCED FROM THE RNA, AND NUCLEOSIDE COMPOUND RIKEN (JP) 2013-02-28 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20130052710-A1 RNA INCLUDING NUCLEOSIDE COMPOUND, METHOD FOR REGULATING AMOUNT OF PROTEIN PRODUCED FROM THE RNA, AND NUCLEOSIDE COMPOUND RNMT, NSUN2, RNGTT PNP 22/4885FGFR1 4325/4885FGFR2 4803/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.