SCHEMBL14716575

SCHEMBL14716575

Nc1nc2nc(N=Nc3ccccc3)[nH]c2c(=O)[nH]1

nearest known ligand 0.58

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
FGFR1 P11362 3/20 0.58
FGFR2 P21802 3/20 0.58
PNP P00491 8/20 0.55
ALDH1A1 P00352 2/20 0.53
CYP1A2 P05177 1/20 0.53
HIF1A Q16665 1/20 0.53
KDM4E B2RXH2 1/20 0.45
MEN1 O00255 1/20 0.45
MAPT P10636 1/20 0.45
THRB P10828 1/20 0.45
HPGD P15428 1/20 0.45
KMT2A Q03164 1/20 0.45
HSD17B10 Q99714 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14716514 0.82 FGFR1 (0.48) FGFR1FGFR2PNPKDM4EMEN1
SCHEMBL14716708 0.82 PNP (0.47) FGFR1FGFR2PNP
SCHEMBL12320442 0.77 ALDH1A1 (0.53) PNPALDH1A1CYP1A2HIF1AKDM4E
SCHEMBL14716576 0.77 ALDH1A1 (0.53) PNPALDH1A1CYP1A2HIF1AKDM4E
SCHEMBL1301998 0.76 PNP (0.68) FGFR1FGFR2PNPALDH1A1KDM4E
SCHEMBL1286943 0.74 FGFR1 (1.00) FGFR1FGFR2PNPALDH1A1MEN1
SCHEMBL14716553 0.73 PNP (0.44) FGFR1FGFR2PNPALDH1A1KDM4E
8-Aminoguanine SCHEMBL21761 0.73 PNP (1.00) FGFR1FGFR2PNPALDH1A1HIF1A
SCHEMBL11498906 0.72 FGFR1 (0.47) FGFR1FGFR2PNPALDH1A1MEN1
SCHEMBL10339631 0.72 PNP (0.61) FGFR1FGFR2PNPALDH1A1KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-108273478-B Formaldehyde removal composition and product 李怀玉 2021-03-02 CN disclosed
CN-108273478-A A kind of formaldehyde removing composition and product 李怀玉 2018-07-13 CN disclosed
US-9458515-B2 RNA including nucleoside compound, method for regulating amount of protein produced from the RNA, and nucleoside compound RIKEN (JP) 2016-10-04 US disclosed
US-20130052710-A1 RNA INCLUDING NUCLEOSIDE COMPOUND, METHOD FOR REGULATING AMOUNT OF PROTEIN PRODUCED FROM THE RNA, AND NUCLEOSIDE COMPOUND RIKEN (JP) 2013-02-28 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20130052710-A1 RNA INCLUDING NUCLEOSIDE COMPOUND, METHOD FOR REGULATING AMOUNT OF PROTEIN PRODUCED FROM THE RNA, AND NUCLEOSIDE COMPOUND RNMT, NSUN2, RNGTT FGFR1 4325/4885FGFR2 4803/4885PNP 22/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.