SCHEMBL14720161

SCHEMBL14720161

CN(C(=O)C(F)(F)F)C1CCCC1

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
RAB9A P51151 4/20 0.41
POLB P06746 4/20 0.41
FAAH O00519 1/20 0.41
PHGDH O43175 1/20 0.41
MGLL Q99685 1/20 0.41
ALDH1A1 P00352 1/20 0.41
ATM Q13315 1/20 0.39
CHRM2 P08172 2/20 0.38
CHRM4 P08173 2/20 0.38
CHRM5 P08912 2/20 0.38
CHRM1 P11229 2/20 0.38
CHRM3 P20309 2/20 0.38
HPGD P15428 1/20 0.38
TSHR P16473 1/20 0.38
KCNH2 Q12809 1/20 0.36
ADH1C P00326 1/20 0.35
ADH1A P07327 1/20 0.35
PDK2 Q15119 1/20 0.35
NPC1 O15118 2/20 0.34
ABCC1 P33527 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12234268 0.98 FAAH (0.44) RAB9APOLBFAAHPHGDHMGLL
SCHEMBL19384067 0.91 CHRM2 (0.36) RAB9APOLBFAAHPHGDHMGLL
SCHEMBL15925835 0.83 MCHR1 (0.34) RAB9APOLBCHRM2CHRM4CHRM5
SCHEMBL2339028 0.83 PDK2 (0.33) RAB9APOLBCHRM2CHRM4CHRM5
SCHEMBL16807400 0.83 RAB9A (0.43) RAB9APOLBFAAHPHGDHMGLL
SCHEMBL14500812 0.83 PDK2 (0.33) RAB9APOLBCHRM2CHRM4CHRM5
SCHEMBL12211963 0.83 PDK2 (0.33) RAB9APOLBCHRM2CHRM4CHRM5
SCHEMBL13240702 0.82 DPP4 (0.34) RAB9APOLBCHRM2CHRM4CHRM5
SCHEMBL4965772 0.82 POLB (0.33) RAB9APOLBCHRM2CHRM4CHRM5
SCHEMBL12385945 0.82 DPP4 (0.34) RAB9APOLBCHRM2CHRM4CHRM5

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2744771-B1 C-HALOGEN BOND FORMATION UNIV PRINCETON (US) 2020-10-21 EP disclosed
EP-2744771-B1 C-HALOGEN BOND FORMATION UNIV PRINCETON (US) 2020-10-21 EP disclosed
US-20200190012-A1 C-HALOGEN BOND FORMATION THE TRUSTEES OF PRINCETON UNIVERSITY (US) 2020-06-18 US disclosed
US-20200190012-A1 C-HALOGEN BOND FORMATION THE TRUSTEES OF PRINCETON UNIVERSITY (US) 2020-06-18 US disclosed
US-20190127311-A1 C-HALOGEN BOND FORMATION THE TRUSTEES OF PRINCETON UNIVERSITY (US) 2019-05-02 US disclosed
US-20190127311-A1 C-HALOGEN BOND FORMATION THE TRUSTEES OF PRINCETON UNIVERSITY (US) 2019-05-02 US disclosed
US-10196341-B2 C-halogen bond formation THE TRUSTEES OF PRINCETON UNIVERSITY (US) 2019-02-05 US disclosed
US-10196341-B2 C-halogen bond formation THE TRUSTEES OF PRINCETON UNIVERSITY (US) 2019-02-05 US disclosed
US-20160264512-A1 C-HALOGEN BOND FORMATION THE TRUSTEES OF PRINCETON UNIVERSITY (US) 2016-09-15 US disclosed
US-20160264512-A1 C-HALOGEN BOND FORMATION THE TRUSTEES OF PRINCETON UNIVERSITY (US) 2016-09-15 US disclosed
US-20150031768-A1 C-HALOGEN BOND FORMATION NATIONAL SCIENCE FOUNDATION 2015-01-29 US disclosed
US-20140249329-A1 C-HALOGEN BOND FORMATION THE TRUSTEES OF PRINCETON UNIVERSITY (US) 2014-09-04 US disclosed
US-20140249329-A1 C-HALOGEN BOND FORMATION THE TRUSTEES OF PRINCETON UNIVERSITY (US) 2014-09-04 US disclosed
US-20140227184-A1 C-HALOGEN BOND FORMATION THE TRUSTEES OF PRINCETON UNIVERSITY (US) 2014-08-14 US disclosed
US-20140227184-A1 C-HALOGEN BOND FORMATION THE TRUSTEES OF PRINCETON UNIVERSITY (US) 2014-08-14 US disclosed
EP-2744771-A1 C-HALOGEN BOND FORMATION The Trustees of Princeton University (US) 2014-06-25 EP disclosed
WO-2013081685-A1 C-HALOGEN BOND FORMATION THE TRUSTEES OF PRINCETON UNIVERSITY (US) 2013-06-06 WO disclosed
WO-2013081685-A1 C-HALOGEN BOND FORMATION THE TRUSTEES OF PRINCETON UNIVERSITY (US) 2013-06-06 WO disclosed
WO-2013028639-A1 C-HALOGEN BOND FORMATION THE TRUSTEES OF PRINCETON UNIVERSITY (US) 2013-02-28 WO disclosed
WO-2013028639-A1 C-HALOGEN BOND FORMATION THE TRUSTEES OF PRINCETON UNIVERSITY (US) 2013-02-28 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20200190012-A1 C-HALOGEN BOND FORMATION CBR3, FOS, CBR1 RAB9A 2813/4885POLB 587/4885FAAH 1008/4885
US-20140227184-A1 C-HALOGEN BOND FORMATION CBR3, FOS, CBR1 RAB9A 2813/4885POLB 587/4885FAAH 1008/4885
US-20160264512-A1 C-HALOGEN BOND FORMATION FOS, BCL3, CBR3 RAB9A 1969/4885POLB 1857/4885FAAH 1376/4885
US-20190127311-A1 C-HALOGEN BOND FORMATION CBR3, FOS, CBR1 RAB9A 2813/4885POLB 587/4885FAAH 1008/4885
US-20140249329-A1 C-HALOGEN BOND FORMATION CBR3, FOS, CBR1 RAB9A 2813/4885POLB 587/4885FAAH 1008/4885
US-10196341-B2 C-halogen bond formation CBR3, FOS, CBR1 RAB9A 2813/4885POLB 587/4885FAAH 1008/4885
US-20150031768-A1 C-HALOGEN BOND FORMATION CBR3, FOS, CBR1 RAB9A 2813/4885POLB 587/4885FAAH 1008/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.