Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.45 |
| ▸ | AAK1 | Q2M2I8 | 2/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | NAMPT | P43490 | 1/20 | 0.43 |
| ▸ | FPR2 | P25090 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | GRK2 | P25098 | 1/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | IDO1 | P14902 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2297057 | 0.92 | USP30 (0.50) | USP30ALDH1A1MAPTTDP1L3MBTL1 | |
| SCHEMBL31417758 | 0.88 | USP30 (0.61) | USP30ALDH1A1MAPTTDP1L3MBTL1 | |
| SCHEMBL14720196 | 0.83 | HDAC2 (0.46) | ALDH1A1MAPTTDP1L3MBTL1GAA | |
| SCHEMBL26087510 | 0.81 | USP30 (0.44) | USP30NAMPTHDAC1HDAC2POLB | |
| SCHEMBL30349449 | 0.81 | USP30 (0.44) | USP30NAMPTHDAC1HDAC2POLB | |
| SCHEMBL24362344 | 0.80 | USP30 (0.56) | USP30NAMPTFPR2IDO1 | |
| SCHEMBL29599473 | 0.80 | USP30 (0.56) | USP30NAMPTFPR2IDO1 | |
| SCHEMBL3809292 | 0.80 | GPR119 (0.54) | USP30MAPTSMN1; SMN2POLB | |
| SCHEMBL26087416 | 0.79 | LIPE (0.43) | USP30NAMPTHDAC1HDAC2 | |
| SCHEMBL20893623 | 0.78 | USP30 (0.54) | USP30AAK1NAMPTPOLBIDO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013028445-A1 | FATTY ACID SYNTHASE INHIBITORS | GLAXOSMITHKLINE LLC (US) | 2013-02-28 | — | — | WO | disclosed |