Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 6/20 | 0.34 |
| ▸ | SRD5A2 | P31213 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | KDM2B | Q8NHM5 | 2/20 | 0.31 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.30 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.30 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14720802 | 0.82 | HRH3 (0.39) | HRH3SRD5A2MEN1KMT2AMCHR1 | |
| SCHEMBL14720768 | 0.74 | KCNH2 (0.44) | HRH3SRD5A2MEN1KMT2AALDH1A1 | |
| SCHEMBL14720413 | 0.73 | LTA4H (0.38) | HRH3SRD5A2 | |
| SCHEMBL14723074 | 0.72 | HRH3 (0.37) | HRH3SRD5A2MEN1KMT2AKDM2B | |
| SCHEMBL14731165 | 0.72 | HRH3 (0.33) | HRH3SRD5A2MEN1KMT2AKDM2B | |
| SCHEMBL14720491 | 0.72 | HRH3 (0.45) | HRH3SRD5A2MEN1KMT2AALDH1A1 | |
| SCHEMBL14731085 | 0.72 | HRH3 (0.40) | HRH3SRD5A2KMT2AMCHR1ALDH1A1 | |
| SCHEMBL14721067 | 0.72 | SRD5A2 (0.42) | HRH3SRD5A2ALDH1A1KDM2B | |
| SCHEMBL14731083 | 0.71 | SRD5A2 (0.46) | HRH3SRD5A2KMT2AMCHR1ALDH1A1 | |
| SCHEMBL14720457 | 0.70 | HRH3 (0.33) | HRH3SRD5A2MCHR1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013027001-A1 | COMPOUNDS AND THEIR USE TO TREAT HISTAMINE H3 RELATED DISORDERS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2013-02-28 | — | — | WO | claimed |
| WO-2013027001-A1 | COMPOUNDS AND THEIR USE TO TREAT HISTAMINE H3 RELATED DISORDERS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2013-02-28 | — | — | WO | disclosed |
| WO-2013027001-A1 | COMPOUNDS AND THEIR USE TO TREAT HISTAMINE H3 RELATED DISORDERS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2013-02-28 | — | — | WO | disclosed |