Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 6/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | SRD5A2 | P31213 | 4/20 | 0.38 |
| ▸ | KDM2B | Q8NHM5 | 2/20 | 0.35 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.33 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.33 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.33 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.32 |
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.32 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.32 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14720467 | 0.82 | HRH3 (0.34) | HRH3MEN1KMT2ASRD5A2KDM2B | |
| SCHEMBL14731165 | 0.81 | HRH3 (0.33) | HRH3MEN1KMT2ASRD5A2KDM2B | |
| SCHEMBL14723074 | 0.81 | HRH3 (0.37) | HRH3MEN1KMT2ASRD5A2KDM2B | |
| SCHEMBL14720608 | 0.78 | HRH3 (0.43) | HRH3SRD5A2MCHR1 | |
| SCHEMBL14720522 | 0.78 | HRH3 (0.39) | HRH3SRD5A2KDM2BMCHR1CHRM2 | |
| SCHEMBL14720518 | 0.77 | HRH3 (0.46) | HRH3 | |
| SCHEMBL14721067 | 0.77 | SRD5A2 (0.42) | HRH3SRD5A2KDM2B | |
| SCHEMBL14722438 | 0.77 | HRH3 (0.39) | HRH3SRD5A2KDM2BMCHR1CHRM2 | |
| SCHEMBL14720465 | 0.76 | HRH3 (0.36) | HRH3 | |
| SCHEMBL14720720 | 0.76 | SRD5A2 (0.58) | HRH3SRD5A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013027001-A1 | COMPOUNDS AND THEIR USE TO TREAT HISTAMINE H3 RELATED DISORDERS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2013-02-28 | — | — | WO | claimed |
| WO-2013027001-A1 | COMPOUNDS AND THEIR USE TO TREAT HISTAMINE H3 RELATED DISORDERS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2013-02-28 | — | — | WO | disclosed |
| WO-2013027001-A1 | COMPOUNDS AND THEIR USE TO TREAT HISTAMINE H3 RELATED DISORDERS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2013-02-28 | — | — | WO | disclosed |