Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 5/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.45 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | PNMT | P11086 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.36 |
| ▸ | MLNR | O43193 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14720768 | 0.93 | KCNH2 (0.44) | HRH3KCNH2GAAKDM4ETP53 | |
| SCHEMBL14720472 | 0.85 | ALDH1A1 (0.38) | HRH3KCNH2GAAKDM4ETP53 | |
| SCHEMBL14721060 | 0.76 | KCNH2 (0.43) | HRH3KCNH2KDM4ETP53ALDH1A1 | |
| SCHEMBL14720718 | 0.75 | HSD11B1 (0.51) | HRH3KCNH2GAAKDM4EALDH1A1 | |
| SCHEMBL14720578 | 0.75 | KDM4E (0.47) | HRH3GAAKDM4EALDH1A1CYP2D6 | |
| SCHEMBL14720413 | 0.72 | LTA4H (0.38) | HRH3CYP2D6SRD5A2 | |
| SCHEMBL14720467 | 0.72 | HRH3 (0.34) | HRH3ALDH1A1KDM2BSRD5A2MEN1 | |
| SCHEMBL14720573 | 0.72 | SRD5A2 (0.37) | HRH3ALDH1A1MLNRCYP2D6CYP2C19 | |
| SCHEMBL14731083 | 0.70 | SRD5A2 (0.46) | HRH3GAAKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL14720887 | 0.70 | POLB (0.52) | GAAKDM4EALDH1A1SMN1; SMN2POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013027001-A1 | COMPOUNDS AND THEIR USE TO TREAT HISTAMINE H3 RELATED DISORDERS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2013-02-28 | — | — | WO | disclosed |
| WO-2013027001-A1 | COMPOUNDS AND THEIR USE TO TREAT HISTAMINE H3 RELATED DISORDERS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2013-02-28 | — | — | WO | disclosed |