Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 1/20 | 0.44 |
| ▸ | GPR119 | Q8TDV5 | 4/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 4/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | F13A1 | P00488 | 2/20 | 0.40 |
| ▸ | TGM2 | P21980 | 2/20 | 0.40 |
| ▸ | TGM1 | P22735 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | OGA | O60502 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14720686 | 0.83 | GRM5 (0.47) | GRM5GPR119KMT2ANR1H2MAPT | |
| SCHEMBL25391413 | 0.83 | GRM5 (0.49) | GRM5KMT2AMAPTTP53MEN1 | |
| SCHEMBL31288438 | 0.83 | GRM5 (0.49) | GRM5KMT2AMAPTTP53MEN1 | |
| SCHEMBL1602307 | 0.82 | OGA (0.46) | GRM5GPR119KMT2APKMNR1H2 | |
| SCHEMBL20333548 | 0.79 | KMT2A (0.46) | GRM5KMT2APKMNR1H2MAPT | |
| SCHEMBL20304926 | 0.79 | KMT2A (0.46) | GRM5KMT2APKMNR1H2MAPT | |
| SCHEMBL20304927 | 0.79 | KMT2A (0.46) | GRM5KMT2APKMNR1H2MAPT | |
| SCHEMBL15051069 | 0.78 | GPR119 (0.53) | GRM5GPR119MAPTMAPK1SMN1; SMN2 | |
| SCHEMBL14720690 | 0.78 | KMT2A (0.45) | GRM5KMT2APKMNR1H2MAPT | |
| SCHEMBL23868370 | 0.78 | MAPT (0.50) | GRM5GPR119NR1H2MAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013027001-A1 | COMPOUNDS AND THEIR USE TO TREAT HISTAMINE H3 RELATED DISORDERS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2013-02-28 | — | — | WO | disclosed |