Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 2/20 | 0.47 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | F13A1 | P00488 | 2/20 | 0.39 |
| ▸ | TGM2 | P21980 | 2/20 | 0.39 |
| ▸ | TGM1 | P22735 | 2/20 | 0.39 |
| ▸ | CKS1B | P61024 | 1/20 | 0.39 |
| ▸ | SKP1 | P63208 | 1/20 | 0.39 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.39 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | GPR119 | Q8TDV5 | 6/20 | 0.39 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.39 |
| ▸ | RORC | P51449 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31288438 | 0.86 | GRM5 (0.49) | GRM5MKNK1POLBESR2MEN1 | |
| SCHEMBL25391413 | 0.86 | GRM5 (0.49) | GRM5MKNK1POLBESR2MEN1 | |
| SCHEMBL14720478 | 0.83 | GRM5 (0.44) | GRM5F13A1TGM2TGM1MEN1 | |
| SCHEMBL14720896 | 0.81 | GRM5 (0.46) | GRM5MKNK1ESR2MEN1MAPT | |
| SCHEMBL14720274 | 0.81 | ALDH1A1 (0.39) | GRM5POLBTSHRSMN1; SMN2LMNA | |
| SCHEMBL15051069 | 0.81 | GPR119 (0.53) | GRM5POLBCKS1BSKP1SKP2 | |
| SCHEMBL28878298 | 0.79 | GPR119 (0.45) | GPR119 | |
| SCHEMBL23868372 | 0.79 | GRM5 (0.43) | GRM5MKNK1ESR2MAPTNR1H2 | |
| SCHEMBL28878297 | 0.79 | GPR119 (0.45) | GPR119 | |
| SCHEMBL21753276 | 0.79 | GRM5 (0.52) | GRM5POLBCKS1BSKP1SKP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013027001-A1 | COMPOUNDS AND THEIR USE TO TREAT HISTAMINE H3 RELATED DISORDERS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2013-02-28 | — | — | WO | disclosed |