Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.42 |
| ▸ | MCHR1 | Q99705 | 3/20 | 0.33 |
| ▸ | OGA | O60502 | 4/20 | 0.32 |
| ▸ | HTR1D | P28221 | 1/20 | 0.31 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.30 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.30 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.30 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.30 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.30 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14720571 | 1.00 | HRH3 (0.42) | HRH3MCHR1OGAHTR1DSRD5A2 | |
| SCHEMBL14720691 | 1.00 | HRH3 (0.42) | HRH3MCHR1OGAHTR1DSRD5A2 | |
| SCHEMBL14720785 | 0.88 | HRH3 (0.44) | HRH3MCHR1OGAHTR1DMEN1 | |
| SCHEMBL14720784 | 0.88 | HRH3 (0.44) | HRH3MCHR1OGAHTR1DMEN1 | |
| SCHEMBL14720850 | 0.83 | HRH3 (0.37) | HRH3OGAHTR1DSRD5A2CYP2D6 | |
| SCHEMBL14720548 | 0.83 | HRH3 (0.37) | HRH3OGAHTR1DSRD5A2CYP2D6 | |
| SCHEMBL14720549 | 0.83 | HRH3 (0.37) | HRH3OGAHTR1DSRD5A2CYP2D6 | |
| SCHEMBL14720927 | 0.83 | OPRM1 (0.46) | HRH3MCHR1SRD5A2OPRM1OPRD1 | |
| SCHEMBL14720604 | 0.83 | OPRM1 (0.46) | HRH3MCHR1SRD5A2OPRM1OPRD1 | |
| SCHEMBL14720605 | 0.83 | OPRM1 (0.46) | HRH3MCHR1SRD5A2OPRM1OPRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013027001-A1 | COMPOUNDS AND THEIR USE TO TREAT HISTAMINE H3 RELATED DISORDERS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2013-02-28 | — | — | WO | disclosed |
| WO-2013027001-A1 | COMPOUNDS AND THEIR USE TO TREAT HISTAMINE H3 RELATED DISORDERS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2013-02-28 | — | — | WO | disclosed |