Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 5/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | OGA | O60502 | 8/20 | 0.33 |
| ▸ | HTR1D | P28221 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | KLK7 | P49862 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.31 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.31 |
| ▸ | DRD2 | P14416 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14720785 | 1.00 | HRH3 (0.44) | HRH3MEN1LMNAKMT2AALDH1A1 | |
| SCHEMBL14720571 | 0.88 | HRH3 (0.42) | HRH3MEN1KMT2AALDH1A1OGA | |
| SCHEMBL14720691 | 0.88 | HRH3 (0.42) | HRH3MEN1KMT2AALDH1A1OGA | |
| SCHEMBL14720570 | 0.88 | HRH3 (0.42) | HRH3MEN1KMT2AALDH1A1OGA | |
| SCHEMBL14720927 | 0.85 | OPRM1 (0.46) | HRH3MCHR1DRD2 | |
| SCHEMBL14720605 | 0.85 | OPRM1 (0.46) | HRH3MCHR1DRD2 | |
| SCHEMBL14720604 | 0.85 | OPRM1 (0.46) | HRH3MCHR1DRD2 | |
| SCHEMBL14720548 | 0.81 | HRH3 (0.37) | HRH3OGAHTR1D | |
| SCHEMBL14720850 | 0.81 | HRH3 (0.37) | HRH3OGAHTR1D | |
| SCHEMBL14720549 | 0.81 | HRH3 (0.37) | HRH3OGAHTR1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013027001-A1 | COMPOUNDS AND THEIR USE TO TREAT HISTAMINE H3 RELATED DISORDERS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2013-02-28 | — | — | WO | claimed |
| WO-2013027001-A1 | COMPOUNDS AND THEIR USE TO TREAT HISTAMINE H3 RELATED DISORDERS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2013-02-28 | — | — | WO | disclosed |