Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 4/20 | 0.46 |
| ▸ | OPRL1 | P41146 | 4/20 | 0.46 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.42 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.41 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.38 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.37 |
| ▸ | SIGMAR1 | Q99720 | 7/20 | 0.35 |
| ▸ | DRD2 | P14416 | 2/20 | 0.32 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.32 |
| ▸ | CCR6 | P51684 | 1/20 | 0.32 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14720605 | 1.00 | OPRM1 (0.46) | OPRM1OPRL1HRH3MCHR1OPRK1 | |
| SCHEMBL14720927 | 1.00 | OPRM1 (0.46) | OPRM1OPRL1HRH3MCHR1OPRK1 | |
| SCHEMBL14720784 | 0.85 | HRH3 (0.44) | HRH3MCHR1DRD2 | |
| SCHEMBL14720785 | 0.85 | HRH3 (0.44) | HRH3MCHR1DRD2 | |
| SCHEMBL14720571 | 0.83 | HRH3 (0.42) | OPRM1OPRL1HRH3MCHR1OPRK1 | |
| SCHEMBL14720691 | 0.83 | HRH3 (0.42) | OPRM1OPRL1HRH3MCHR1OPRK1 | |
| SCHEMBL14720570 | 0.83 | HRH3 (0.42) | OPRM1OPRL1HRH3MCHR1OPRK1 | |
| SCHEMBL14720811 | 0.80 | HRH3 (0.36) | OPRM1OPRL1HRH3SRD5A2 | |
| SCHEMBL14720966 | 0.80 | HRH3 (0.36) | OPRL1HRH3SRD5A2 | |
| SCHEMBL14720813 | 0.80 | HRH3 (0.36) | OPRM1OPRL1HRH3SRD5A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013027001-A1 | COMPOUNDS AND THEIR USE TO TREAT HISTAMINE H3 RELATED DISORDERS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2013-02-28 | — | — | WO | claimed |
| WO-2013027001-A1 | COMPOUNDS AND THEIR USE TO TREAT HISTAMINE H3 RELATED DISORDERS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2013-02-28 | — | — | WO | disclosed |
| WO-2013027001-A1 | COMPOUNDS AND THEIR USE TO TREAT HISTAMINE H3 RELATED DISORDERS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2013-02-28 | — | — | WO | disclosed |