SCHEMBL14720573

SCHEMBL14720573

CCOCCS(=O)(=O)Cc1ccc(C=C2CCN(C3CCC3)CC2)cc1

nearest known ligand 0.37

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
SRD5A2 P31213 2/20 0.37
POLB P06746 4/20 0.33
HRH3 Q9Y5N1 7/20 0.33
CYP2D6 P10635 4/20 0.33
MLNR O43193 1/20 0.32
ALDH1A1 P00352 1/20 0.32
RECQL P46063 1/20 0.31
SMN1; SMN2 Q16637 1/20 0.31
MEN1 O00255 1/20 0.31
KMT2A Q03164 1/20 0.31
SRD5A1 P18405 1/20 0.31
PKM P14618 1/20 0.31
CYP3A4 P08684 1/20 0.30
TSHR P16473 1/20 0.30
CYP2C19 P33261 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14720472 0.85 ALDH1A1 (0.38) POLBHRH3CYP2D6MLNRALDH1A1
SCHEMBL14720768 0.76 KCNH2 (0.44) SRD5A2POLBHRH3CYP2D6MLNR
SCHEMBL14721184 0.73 POLB (0.39) SRD5A2POLBHRH3CYP2D6ALDH1A1
SCHEMBL14721402 0.73 MAPT (0.44) SRD5A2POLBHRH3ALDH1A1SMN1; SMN2
SCHEMBL14720491 0.72 HRH3 (0.45) SRD5A2POLBHRH3CYP2D6MLNR
SCHEMBL14721067 0.72 SRD5A2 (0.42) SRD5A2HRH3CYP2D6ALDH1A1SRD5A1
SCHEMBL14721400 0.72 SRD5A2 (0.48) SRD5A2POLBHRH3ALDH1A1KMT2A
SCHEMBL14722546 0.71 USP2 (0.45) SRD5A2HRH3
SCHEMBL14720551 0.71 ALDH1A1 (0.56) POLBALDH1A1SMN1; SMN2
SCHEMBL14731083 0.71 SRD5A2 (0.46) SRD5A2POLBHRH3ALDH1A1SMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2013027001-A1 COMPOUNDS AND THEIR USE TO TREAT HISTAMINE H3 RELATED DISORDERS TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2013-02-28 WO claimed
WO-2013027001-A1 COMPOUNDS AND THEIR USE TO TREAT HISTAMINE H3 RELATED DISORDERS TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2013-02-28 WO disclosed
WO-2013027001-A1 COMPOUNDS AND THEIR USE TO TREAT HISTAMINE H3 RELATED DISORDERS TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2013-02-28 WO disclosed