Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 6/20 | 0.40 |
| ▸ | KDM2B | Q8NHM5 | 2/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 5/20 | 0.37 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.33 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.33 |
| ▸ | PRKACA | P17612 | 1/20 | 0.32 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14720526 | 0.85 | SRD5A2 (0.47) | HRH3KDM2BSRD5A2CYP2D6PRKACA | |
| SCHEMBL14721335 | 0.81 | HRH3 (0.39) | HRH3POLB | |
| SCHEMBL14721067 | 0.79 | SRD5A2 (0.42) | HRH3KDM2BSRD5A2CYP2D6 | |
| SCHEMBL14720884 | 0.76 | HRH3 (0.36) | HRH3SIGMAR1SRD5A2 | |
| SCHEMBL14721173 | 0.76 | LRRK2 (0.54) | HRH3 | |
| SCHEMBL14720745 | 0.76 | CCR1 (0.39) | — | |
| SCHEMBL14720838 | 0.76 | SRD5A2 (0.44) | HRH3KDM2BSRD5A2CYP2D6 | |
| SCHEMBL14720705 | 0.75 | ALDH1A1 (0.44) | HRH3SRD5A2 | |
| SCHEMBL14720804 | 0.74 | IRAK4 (0.35) | HRH3 | |
| SCHEMBL14720367 | 0.73 | HRH3 (0.42) | HRH3KDM2BCYP2D6POLBPDCD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013027001-A1 | COMPOUNDS AND THEIR USE TO TREAT HISTAMINE H3 RELATED DISORDERS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2013-02-28 | — | — | WO | claimed |
| WO-2013027001-A1 | COMPOUNDS AND THEIR USE TO TREAT HISTAMINE H3 RELATED DISORDERS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2013-02-28 | — | — | WO | disclosed |
| WO-2013027001-A1 | COMPOUNDS AND THEIR USE TO TREAT HISTAMINE H3 RELATED DISORDERS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2013-02-28 | — | — | WO | disclosed |