Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.35 |
| ▸ | DRD3 | P35462 | 2/20 | 0.32 |
| ▸ | HTR6 | P50406 | 1/20 | 0.32 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14720692 | 0.74 | HRH3 (0.40) | HRH3 | |
| SCHEMBL14721335 | 0.73 | HRH3 (0.39) | IRAK4HRH3MAPT | |
| SCHEMBL14720521 | 0.71 | SRD5A2 (0.40) | HRH3 | |
| SCHEMBL14720745 | 0.71 | CCR1 (0.39) | — | |
| SCHEMBL14720884 | 0.69 | HRH3 (0.36) | HRH3 | |
| SCHEMBL14721173 | 0.69 | LRRK2 (0.54) | HRH3 | |
| SCHEMBL14720705 | 0.68 | ALDH1A1 (0.44) | HRH3MAPT | |
| SCHEMBL14720792 | 0.66 | HRH3 (0.39) | HRH3 | |
| SCHEMBL14720793 | 0.65 | IRAK4 (0.41) | IRAK4HRH3 | |
| SCHEMBL14720734 | 0.65 | SRD5A2 (0.34) | HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013027001-A1 | COMPOUNDS AND THEIR USE TO TREAT HISTAMINE H3 RELATED DISORDERS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2013-02-28 | — | — | WO | disclosed |