Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 12/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.33 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.32 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.32 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.32 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.32 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14722348 | 0.86 | HRH3 (0.38) | HRH3CYP2D6KMT2ARAB9AMEN1 | |
| SCHEMBL14722832 | 0.84 | OGA (0.38) | HRH3CYP2D6KMT2ARAB9AMEN1 | |
| SCHEMBL14720972 | 0.78 | HRH3 (0.42) | HRH3CYP2D6MCHR1 | |
| SCHEMBL14722974 | 0.77 | HRH3 (0.39) | HRH3CYP2D6MCHR1NPC1 | |
| SCHEMBL14722240 | 0.75 | HRH3 (0.33) | HRH3CYP2D6 | |
| SCHEMBL14721216 | 0.73 | HRH3 (0.40) | HRH3CYP2D6 | |
| SCHEMBL14720490 | 0.73 | HRH3 (0.49) | HRH3CYP2D6RAB9A | |
| SCHEMBL14721944 | 0.73 | HRH3 (0.37) | HRH3CYP2D6KMT2AMCHR1 | |
| SCHEMBL14721508 | 0.72 | HRH3 (0.38) | HRH3CYP2D6 | |
| SCHEMBL14720398 | 0.71 | HRH3 (0.45) | HRH3CYP2D6CHRM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013027001-A1 | COMPOUNDS AND THEIR USE TO TREAT HISTAMINE H3 RELATED DISORDERS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2013-02-28 | — | — | WO | claimed |
| WO-2013027001-A1 | COMPOUNDS AND THEIR USE TO TREAT HISTAMINE H3 RELATED DISORDERS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2013-02-28 | — | — | WO | disclosed |
| WO-2013027001-A1 | COMPOUNDS AND THEIR USE TO TREAT HISTAMINE H3 RELATED DISORDERS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2013-02-28 | — | — | WO | disclosed |