SCHEMBL14722348

SCHEMBL14722348

Cc1cc(COCc2ccc(C=C3CCN(C4CCC4)CC3)cc2)no1

nearest known ligand 0.38

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
HRH3 Q9Y5N1 8/20 0.38
CYP2D6 P10635 4/20 0.38
AKT1 P31749 1/20 0.37
KMT2A Q03164 2/20 0.32
RAB9A P51151 2/20 0.32
MEN1 O00255 1/20 0.32
ALOX5AP P20292 1/20 0.31
FEN1 P39748 1/20 0.31
SRD5A2 P31213 1/20 0.31
NMT1 P30419 1/20 0.31
NPC1 O15118 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14720755 0.86 HRH3 (0.40) HRH3CYP2D6KMT2ARAB9AMEN1
SCHEMBL14722240 0.83 HRH3 (0.33) HRH3CYP2D6SRD5A2
SCHEMBL14720672 0.76 HRH3 (0.38) HRH3CYP2D6SRD5A2
SCHEMBL14721216 0.73 HRH3 (0.40) HRH3CYP2D6SRD5A2
SCHEMBL14720738 0.73 HRH3 (0.42) HRH3CYP2D6SRD5A2
SCHEMBL14722832 0.72 OGA (0.38) HRH3CYP2D6KMT2ARAB9AMEN1
SCHEMBL14721508 0.72 HRH3 (0.38) HRH3CYP2D6SRD5A2
SCHEMBL14720972 0.72 HRH3 (0.42) HRH3CYP2D6SRD5A2
SCHEMBL14721067 0.71 SRD5A2 (0.42) HRH3CYP2D6SRD5A2
SCHEMBL14722914 0.70 MAOA (0.39) HRH3RAB9ANPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2013027001-A1 COMPOUNDS AND THEIR USE TO TREAT HISTAMINE H3 RELATED DISORDERS TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2013-02-28 WO claimed
WO-2013027001-A1 COMPOUNDS AND THEIR USE TO TREAT HISTAMINE H3 RELATED DISORDERS TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2013-02-28 WO disclosed
WO-2013027001-A1 COMPOUNDS AND THEIR USE TO TREAT HISTAMINE H3 RELATED DISORDERS TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2013-02-28 WO disclosed