Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | HPGD | P15428 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.31 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.31 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.31 |
| ▸ | PDE4A | P27815 | 1/20 | 0.30 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.30 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.30 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.30 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.30 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14721320 | 0.88 | ALDH1A1 (0.32) | MEN1KMT2AALDH1A1HPGDTP53 | |
| SCHEMBL14722942 | 0.85 | ALDH1A1 (0.34) | MEN1KMT2AALDH1A1HPGDKDM4E | |
| SCHEMBL14725340 | 0.84 | TUBB4A (0.40) | MEN1KMT2AABCB1ABCG2 | |
| SCHEMBL14721961 | 0.77 | CYP19A1 (0.39) | MEN1KMT2AALDH1A1HPGDKDM4E | |
| SCHEMBL14721638 | 0.73 | TUBB4A (0.34) | MEN1KMT2AALDH1A1HPGDKDM4E | |
| SCHEMBL14723556 | 0.73 | TUBB4A (0.34) | MEN1KMT2AALDH1A1HPGDKDM4E | |
| SCHEMBL14721807 | 0.73 | KDM4E (0.39) | MEN1KMT2AALDH1A1HPGDKDM4E | |
| SCHEMBL14722126 | 0.72 | NPSR1 (0.35) | MEN1KMT2AALDH1A1HPGDKDM4E | |
| SCHEMBL14725473 | 0.72 | ALDH1A1 (0.35) | MEN1KMT2AALDH1A1HPGDKDM4E | |
| SCHEMBL14725341 | 0.70 | TUBB4A (0.41) | MEN1KMT2AABCB1ABCG2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013026942-A1 | TUBULIN BINDING AGENTS | THE PROVOST, FELLOWS, FOUNDATION SCHOLARS, AND THE OTHER MEMBERS OF BOARD, OF THE COLLEGE OF THE HOLY AND UNDIVIDED TRINITY OF QUEEN ELIZABETH, NEAR DUBLIN (IE) | 2013-02-28 | — | — | WO | disclosed |