SCHEMBL14722754

SCHEMBL14722754

C=C(Cn1c(=O)oc2ccccc21)N1CCN(C2CCCCC2)CC1

nearest known ligand 0.67

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
▸ CDYL Q9Y232 5/20 0.66
▸ CBX7 O95931 4/20 0.66
▸ CDYL2 Q8N8U2 4/20 0.66
▸ CDY1; CDY1B Q9Y6F8 3/20 0.66
▸ ALDH1A1 P00352 3/20 0.53
▸ MEN1 O00255 1/20 0.53
▸ KMT2A Q03164 1/20 0.53
▸ MAPK1 P28482 1/20 0.53
▸ HTT P42858 1/20 0.52
▸ POLB P06746 1/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4386342 0.82 ALDH1A1 (0.75) CDYLCBX7CDYL2CDY1; CDY1BALDH1A1
SCHEMBL4379269 0.81 ALDH1A1 (0.73) CDYLCBX7CDYL2CDY1; CDY1BALDH1A1
SCHEMBL12124515 0.80 — —
SCHEMBL12124405 0.78 — —
SCHEMBL12124510 0.78 — —
SCHEMBL12124489 0.78 CBX7 (0.55) CDYLCBX7CDYL2CDY1; CDY1B
SCHEMBL12124511 0.77 — —
SCHEMBL12124415 0.77 — —
SCHEMBL4385817 0.75 ALDH1A1 (0.63) CDYLCBX7CDYL2CDY1; CDY1BALDH1A1
SCHEMBL1862937 0.73 CHRM4 (0.56) CDYLCBX7CDYL2CDY1; CDY1B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20170349554-A1 COMPOSITIONS AND METHODS FOR TREATING NEURODEGENERATIVE DISEASE COGNITION THERAPEUTICS, INC. 2017-12-07 — — US disclosed
US-20140378460-A1 COMPOSITIONS AND METHODS FOR TREATING NEURODEGENERATIVE DISEASE COGNITION THERAPEUTICS, INC. (US) 2014-12-25 — — US disclosed
EP-2747768-A2 COMPOSITIONS AND METHODS FOR TREATING NEURODEGENERATIVE DISEASE Cognition Therapeutics, Inc. (US) 2014-07-02 — — EP disclosed
WO-2013029060-A2 COMPOSITIONS AND METHODS FOR TREATING NEURODEGENERATIVE DISEASE COGNITION THERAPEUTICS, INC. (US) 2013-02-28 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20140378460-A1 COMPOSITIONS AND METHODS FOR TREATING NEURODEGENERATIVE DISEASE TMEM97, SLC18A2, SIGMAR1 CDYL 3080/4885CBX7 3383/4885CDYL2 1751/4885
US-20170349554-A1 COMPOSITIONS AND METHODS FOR TREATING NEURODEGENERATIVE DISEASE TMEM97, SLC18A2, SIGMAR1 CDYL 3080/4885CBX7 3383/4885CDYL2 1751/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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