SCHEMBL14722985

SCHEMBL14722985

CC(C)(C)OC(=O)N[C@H]1CN(c2ncc(C(=O)O)cn2)C[C@@H]1c1ccccc1F

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
RBP4 P02753 1/20 0.45
PDE5A O76074 1/20 0.39
KDM1A O60341 3/20 0.39
MAOB P27338 1/20 0.39
CKS1B P61024 1/20 0.38
SKP1 P63208 1/20 0.38
SKP2 Q13309 1/20 0.38
HDAC3 O15379 1/20 0.37
HDAC4 P56524 1/20 0.37
HDAC1 Q13547 1/20 0.37
HDAC7 Q8WUI4 1/20 0.37
HDAC2 Q92769 1/20 0.37
HDAC10 Q969S8 1/20 0.37
HDAC11 Q96DB2 1/20 0.37
HDAC8 Q9BY41 1/20 0.37
HDAC6 Q9UBN7 1/20 0.37
HDAC9 Q9UKV0 1/20 0.37
HDAC5 Q9UQL6 1/20 0.37
NTRK1 P04629 3/20 0.35
SLC6A9 P48067 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6128111 0.92 NR1H2 (0.39) RBP4KDM1AMAOBCKS1BSKP1
SCHEMBL6128115 0.89 NTRK1 (0.41) RBP4KDM1AHDAC3HDAC4HDAC1
SCHEMBL14722979 0.89 NTRK1 (0.41) RBP4KDM1AHDAC3HDAC4HDAC1
SCHEMBL14730335 0.88 DPP4 (0.38) RBP4KDM1AMAOBCKS1BSKP1
SCHEMBL6128110 0.85 RBP4 (0.36) RBP4KDM1AMAOBCKS1BSKP1
SCHEMBL14723477 0.85 RBP4 (0.36) RBP4KDM1AMAOBCKS1BSKP1
SCHEMBL14723522 0.81 NR1H2 (0.42) KDM1AHDAC3HDAC4HDAC1HDAC7
SCHEMBL14723584 0.80 NR1H2 (0.41) KDM1ANTRK1EIF2AK4F2R
SCHEMBL610993 0.79 NTRK1 (0.40) KDM1AHDAC3HDAC4HDAC1HDAC7
SCHEMBL1724455 0.79 NTRK1 (0.40) KDM1AHDAC3HDAC4HDAC1HDAC7

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2013026587-A1 1,4 DISUBSTITUTED PYRROLIDINE - 3 - YL -AMINE DERIVATIVES AND THEIR USE FOR THE TREATMENT OF METABOLIC DISORDERS PROSIDION LIMITED (GB) 2013-02-28 WO disclosed