Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN2 | P17706 | 2/20 | 0.44 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.44 |
| ▸ | PNLIP | P16233 | 3/20 | 0.43 |
| ▸ | RPS6KA5 | O75582 | 2/20 | 0.39 |
| ▸ | MAPKAPK2 | P49137 | 2/20 | 0.39 |
| ▸ | ATP1A1 | P05023 | 3/20 | 0.38 |
| ▸ | ATP1B1 | P05026 | 3/20 | 0.38 |
| ▸ | ATP1A3 | P13637 | 3/20 | 0.38 |
| ▸ | ATP1B2 | P14415 | 3/20 | 0.38 |
| ▸ | ATP1A2 | P50993 | 3/20 | 0.38 |
| ▸ | ATP1B3 | P54709 | 3/20 | 0.38 |
| ▸ | FXYD2 | P54710 | 3/20 | 0.38 |
| ▸ | ATP1A4 | Q13733 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15945065 | 1.00 | PTPN2 (0.44) | PTPN2PTPN1PNLIPRPS6KA5MAPKAPK2 | |
| SCHEMBL12658772 | 1.00 | PTPN2 (0.44) | PTPN2PTPN1PNLIPRPS6KA5MAPKAPK2 | |
| SCHEMBL12659027 | 0.88 | PNLIP (0.44) | PTPN2PTPN1PNLIPRPS6KA5MAPKAPK2 | |
| SCHEMBL13722523 | 0.85 | PTPN1 (0.56) | PTPN2PTPN1PNLIPRPS6KA5MAPKAPK2 | |
| SCHEMBL16001864 | 0.85 | PTPN1 (0.56) | PTPN2PTPN1PNLIPRPS6KA5MAPKAPK2 | |
| SCHEMBL24264493 | 0.85 | PTPN1 (0.56) | PTPN2PTPN1PNLIPRPS6KA5MAPKAPK2 | |
| SCHEMBL9864391 | 0.85 | PTPN1 (0.56) | PTPN2PTPN1PNLIPRPS6KA5MAPKAPK2 | |
| SCHEMBL25439738 | 0.81 | PNLIP (0.46) | PTPN2PTPN1PNLIPRPS6KA5MAPKAPK2 | |
| SCHEMBL25434656 | 0.81 | PNLIP (0.46) | PTPN2PTPN1PNLIPRPS6KA5MAPKAPK2 | |
| SCHEMBL25436685 | 0.81 | PNLIP (0.46) | PTPN2PTPN1PNLIPRPS6KA5MAPKAPK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200190012-A1 | C-HALOGEN BOND FORMATION | THE TRUSTEES OF PRINCETON UNIVERSITY (US) | 2020-06-18 | — | — | US | claimed |
| US-20190127311-A1 | C-HALOGEN BOND FORMATION | THE TRUSTEES OF PRINCETON UNIVERSITY (US) | 2019-05-02 | — | — | US | claimed |
| US-10196341-B2 | C-halogen bond formation | THE TRUSTEES OF PRINCETON UNIVERSITY (US) | 2019-02-05 | — | — | US | claimed |
| EP-2744771-A1 | C-HALOGEN BOND FORMATION | The Trustees of Princeton University (US) | 2014-06-25 | — | — | EP | claimed |
| WO-2013081685-A1 | C-HALOGEN BOND FORMATION | THE TRUSTEES OF PRINCETON UNIVERSITY (US) | 2013-06-06 | — | — | WO | claimed |
| WO-2013028639-A1 | C-HALOGEN BOND FORMATION | THE TRUSTEES OF PRINCETON UNIVERSITY (US) | 2013-02-28 | — | — | WO | claimed |
| EP-2744771-B1 | C-HALOGEN BOND FORMATION | UNIV PRINCETON (US) | 2020-10-21 | — | — | EP | disclosed |
| US-20200190012-A1 | C-HALOGEN BOND FORMATION | THE TRUSTEES OF PRINCETON UNIVERSITY (US) | 2020-06-18 | — | — | US | disclosed |
| US-20190127311-A1 | C-HALOGEN BOND FORMATION | THE TRUSTEES OF PRINCETON UNIVERSITY (US) | 2019-05-02 | — | — | US | disclosed |
| US-20160264512-A1 | C-HALOGEN BOND FORMATION | THE TRUSTEES OF PRINCETON UNIVERSITY (US) | 2016-09-15 | — | — | US | disclosed |
| WO-2015134467-A1 | METHODS AND COMPOSITIONS FOR DIRECT RADIOACTIVE LABELING OF BIO-ACTIVE MOLECULES AND BUILDING BLOCKS | THE TRUSTEES OF PRINCETON UNIVERSITY (US) | 2015-09-11 | — | — | WO | disclosed |
| WO-2015054476-A1 | C-HALOGEN BOND FORMATION | THE TRUSTEES OF PRINCETON UNIVERSITY (US) | 2015-04-16 | — | — | WO | disclosed |
| EP-2744771-A1 | C-HALOGEN BOND FORMATION | The Trustees of Princeton University (US) | 2014-06-25 | — | — | EP | disclosed |
| WO-2013081685-A1 | C-HALOGEN BOND FORMATION | THE TRUSTEES OF PRINCETON UNIVERSITY (US) | 2013-06-06 | — | — | WO | disclosed |
| WO-2013028639-A1 | C-HALOGEN BOND FORMATION | THE TRUSTEES OF PRINCETON UNIVERSITY (US) | 2013-02-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200190012-A1 | C-HALOGEN BOND FORMATION | CBR3, FOS, CBR1 | PTPN2 4601/4885PTPN1 4595/4885PNLIP 4272/4885 |
| US-20160264512-A1 | C-HALOGEN BOND FORMATION | FOS, BCL3, CBR3 | PTPN2 4582/4885PTPN1 4658/4885PNLIP 4580/4885 |
| US-20190127311-A1 | C-HALOGEN BOND FORMATION | CBR3, FOS, CBR1 | PTPN2 4601/4885PTPN1 4595/4885PNLIP 4272/4885 |
| US-10196341-B2 | C-halogen bond formation | CBR3, FOS, CBR1 | PTPN2 4601/4885PTPN1 4595/4885PNLIP 4272/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.