Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 1/20 | 0.42 |
| ▸ | BRD4 | O60885 | 1/20 | 0.42 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.42 |
| ▸ | GPR119 | Q8TDV5 | 14/20 | 0.41 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.39 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.37 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.37 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.37 |
| ▸ | SMPD3 | Q9NY59 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18280165 | 0.79 | USP30 (0.47) | GRM5GPR119PTPN2PTPN1PTPN6 | |
| SCHEMBL4635083 | 0.76 | GRM5 (0.46) | GRM5GPR119 | |
| SCHEMBL1870570 | 0.76 | NR1H2 (0.54) | GRM5GPR119PTPN2PTPN1PTPN6 | |
| SCHEMBL5497099 | 0.76 | MEN1 (0.55) | GRM5 | |
| SCHEMBL14720896 | 0.76 | GRM5 (0.46) | GRM5GPR119 | |
| SCHEMBL1473227 | 0.76 | GPR119 (0.51) | GRM5GPR119 | |
| SCHEMBL15699606 | 0.75 | ALDH1A1 (0.54) | GRM5GPR119 | |
| SCHEMBL20304919 | 0.75 | SRD5A2 (0.55) | GRM5GPR119 | |
| SCHEMBL16113569 | 0.74 | MAPT (0.54) | GRM5GPR119 | |
| SCHEMBL31701014 | 0.74 | PTPN2 (0.46) | GRM5GPR119PTPN2PTPN1PTPN6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013027001-A1 | COMPOUNDS AND THEIR USE TO TREAT HISTAMINE H3 RELATED DISORDERS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2013-02-28 | — | — | WO | disclosed |