Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | RECQL | P46063 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 3/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 6/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | POLM | Q9NP87 | 1/20 | 0.42 |
| ▸ | POLK | Q9UBT6 | 1/20 | 0.42 |
| ▸ | POLL | Q9UGP5 | 1/20 | 0.42 |
| ▸ | POLH | Q9Y253 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7892385 | 0.91 | MEN1 (0.60) | KDM4EKMT2AMEN1RECQLTSHR | |
| SCHEMBL13425197 | 0.90 | HDAC1 (0.54) | KDM4EKMT2AMEN1RECQLTSHR | |
| SCHEMBL7209562 | 0.89 | MEN1 (0.61) | KDM4EKMT2AMEN1RECQLTSHR | |
| SCHEMBL14723636 | 0.88 | SLC6A3 (0.51) | KDM4EKMT2AMEN1RECQLALDH1A1 | |
| SCHEMBL5706016 | 0.87 | KDM4E (0.63) | KDM4EKMT2AMEN1RECQLTSHR | |
| SCHEMBL8499422 | 0.87 | MEN1 (0.61) | KDM4EKMT2AMEN1RECQLTSHR | |
| SCHEMBL8498851 | 0.84 | TSHR (0.65) | KDM4EKMT2AMEN1RECQLTSHR | |
| SCHEMBL14723638 | 0.83 | MEN1 (0.51) | KDM4EKMT2AMEN1RECQLALDH1A1 | |
| SCHEMBL7351148 | 0.81 | KDM4E (0.56) | KDM4EKMT2AMEN1RECQLTSHR | |
| SCHEMBL29055864 | 0.80 | MEN1 (0.46) | KDM4EKMT2AMEN1RECQLTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9199923-B2 | Histone deacetylase inhibitors | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2015-12-01 | — | — | US | disclosed |
| US-20150038581-A1 | HISTONE DEACETYLASE INHIBITORS | Harvard University & Medical School | 2015-02-05 | — | — | US | disclosed |
| US-8383855-B2 | Histone deacetylase inhibitors | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2013-02-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150038581-A1 | HISTONE DEACETYLASE INHIBITORS | HDAC1, HDAC11, HDAC7 | KDM4E 172/4885KMT2A 38/4885MEN1 888/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.