Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 2/20 | 0.31 |
| ▸ | CA2 | P00918 | 2/20 | 0.31 |
| ▸ | CA4 | P22748 | 1/20 | 0.31 |
| ▸ | CA9 | Q16790 | 1/20 | 0.31 |
| ▸ | CA7 | P43166 | 1/20 | 0.31 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27524175 | 0.81 | CA2 (0.39) | KDM4ECA2CA4CA9CA7 | |
| SCHEMBL16995198 | 0.79 | L3MBTL1 (0.37) | L3MBTL1CYP1A2PKMPTK2BALDH1A1 | |
| SCHEMBL21540750 | 0.79 | ALDH1A1 (0.41) | L3MBTL1CYP1A2PKMPTK2BALDH1A1 | |
| SCHEMBL10861324 | 0.79 | KDM4E (0.37) | KDM4ECYP2D6ALDH1A1 | |
| SCHEMBL28307782 | 0.78 | ALDH1A1 (0.35) | KDM4ECYP1A2ALDH1A1 | |
| SCHEMBL12591338 | 0.77 | EPHX1 (0.44) | KDM4EL3MBTL1CYP1A2PKMPTK2B | |
| SCHEMBL16407995 | 0.77 | POLB (0.37) | L3MBTL1CYP1A2PKMPTK2B | |
| SCHEMBL7918442 | 0.77 | — | — | |
| SCHEMBL11032929 | 0.77 | — | — | |
| SCHEMBL1993072 | 0.77 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1836174-B1 | ARYL NITROGEN-CONTAINING BICYCLIC COMPOUNDS AND THEIR USE AS KINASE INHIBITORS | AMGEN INC (US) | 2013-02-27 | — | — | EP | disclosed |