Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP2 | P50579 | 3/20 | 0.38 |
| ▸ | IL1RN | P18510 | 11/20 | 0.36 |
| ▸ | ERAP2 | Q6P179 | 11/20 | 0.36 |
| ▸ | ERAP1 | Q9NZ08 | 9/20 | 0.36 |
| ▸ | PSMB5 | P28074 | 2/20 | 0.34 |
| ▸ | CTSD | P07339 | 1/20 | 0.34 |
| ▸ | BIRC2 | Q13490 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14721273 | 0.94 | METAP2 (0.40) | METAP2IL1RNERAP2ERAP1PSMB5 | |
| SCHEMBL14725404 | 0.88 | PSMB5 (0.36) | IL1RNERAP2ERAP1PSMB5BIRC2 | |
| SCHEMBL14725258 | 0.84 | METAP2 (0.40) | METAP2IL1RNERAP2ERAP1PSMB5 | |
| SCHEMBL14721499 | 0.83 | PSEN1 (0.40) | — | |
| Carbamic Acid SCHEMBL14722093 | 0.77 | SRC (0.39) | — | |
| SCHEMBL14721711 | 0.76 | GSK3B (0.36) | — | |
| SCHEMBL14725254 | 0.75 | METAP2 (0.42) | METAP2IL1RNERAP2ERAP1PSMB5 | |
| SCHEMBL14725272 | 0.75 | METAP2 (0.41) | METAP2IL1RNERAP2ERAP1PSMB5 | |
| SCHEMBL14725494 | 0.73 | PSEN1 (0.42) | — | |
| SCHEMBL14722096 | 0.72 | SRC (0.37) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013026942-A1 | TUBULIN BINDING AGENTS | THE PROVOST, FELLOWS, FOUNDATION SCHOLARS, AND THE OTHER MEMBERS OF BOARD, OF THE COLLEGE OF THE HOLY AND UNDIVIDED TRINITY OF QUEEN ELIZABETH, NEAR DUBLIN (IE) | 2013-02-28 | — | — | WO | disclosed |