Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP2 | P50579 | 3/20 | 0.42 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | IL1RN | P18510 | 4/20 | 0.37 |
| ▸ | ERAP2 | Q6P179 | 4/20 | 0.37 |
| ▸ | ERAP1 | Q9NZ08 | 3/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | LAP3 | P28838 | 2/20 | 0.36 |
| ▸ | ANPEP | P15144 | 2/20 | 0.36 |
| ▸ | RNPEP | Q9H4A4 | 1/20 | 0.36 |
| ▸ | DNPEP | Q9ULA0 | 1/20 | 0.36 |
| ▸ | GPR142 | Q7Z601 | 1/20 | 0.36 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14725272 | 0.99 | METAP2 (0.41) | METAP2AAK1TSHRPOLBNPSR1 | |
| SCHEMBL14725433 | 0.91 | TSHR (0.38) | AAK1TSHRPOLBNPSR1ALDH1A1 | |
| SCHEMBL14725258 | 0.90 | METAP2 (0.40) | METAP2AAK1IL1RNERAP2ERAP1 | |
| SCHEMBL14725528 | 0.87 | REN (0.40) | — | |
| SCHEMBL14725256 | 0.82 | METAP2 (0.39) | METAP2AAK1IL1RNERAP2ERAP1 | |
| SCHEMBL14725450 | 0.82 | AAK1 (0.43) | AAK1TSHR | |
| SCHEMBL14721685 | 0.82 | AAK1 (0.43) | AAK1TSHR | |
| SCHEMBL14725517 | 0.81 | AAK1 (0.44) | AAK1TSHRNPSR1ALDH1A1MAPT | |
| SCHEMBL14725250 | 0.80 | METAP2 (0.39) | METAP2AAK1IL1RNERAP2ERAP1 | |
| SCHEMBL14721273 | 0.79 | METAP2 (0.40) | METAP2AAK1IL1RNERAP2ERAP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013026942-A1 | TUBULIN BINDING AGENTS | THE PROVOST, FELLOWS, FOUNDATION SCHOLARS, AND THE OTHER MEMBERS OF BOARD, OF THE COLLEGE OF THE HOLY AND UNDIVIDED TRINITY OF QUEEN ELIZABETH, NEAR DUBLIN (IE) | 2013-02-28 | — | — | WO | disclosed |