Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 4/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.32 |
| ▸ | CDK1 | P06493 | 1/20 | 0.32 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.32 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14725538 | 0.85 | KDM4E (0.39) | KDM4EMEN1MAPTKMT2AALDH1A1 | |
| SCHEMBL14725260 | 0.85 | TUBB4A (0.41) | EGFRKDM4EMEN1MAPTKMT2A | |
| SCHEMBL14725480 | 0.76 | CA1 (0.33) | — | |
| SCHEMBL14725338 | 0.75 | TUBB4A (0.37) | KDM4EMAPTALDH1A1 | |
| SCHEMBL14725455 | 0.73 | TUBB4A (0.33) | KDM4EMAPTALDH1A1 | |
| SCHEMBL14721851 | 0.70 | TUBB4A (0.48) | KDM4EALDH1A1HPGD | |
| SCHEMBL14722159 | 0.68 | KDM4E (0.32) | KDM4EMEN1MAPTKMT2AALDH1A1 | |
| SCHEMBL14722163 | 0.68 | KDM4E (0.32) | KDM4EMEN1MAPTKMT2AALDH1A1 | |
| SCHEMBL14722148 | 0.68 | TUBB4A (0.48) | KDM4EMEN1MAPTKMT2AALDH1A1 | |
| SCHEMBL14721749 | 0.67 | TUBB4A (0.36) | ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013026942-A1 | TUBULIN BINDING AGENTS | THE PROVOST, FELLOWS, FOUNDATION SCHOLARS, AND THE OTHER MEMBERS OF BOARD, OF THE COLLEGE OF THE HOLY AND UNDIVIDED TRINITY OF QUEEN ELIZABETH, NEAR DUBLIN (IE) | 2013-02-28 | — | — | WO | disclosed |