Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.33 |
| ▸ | HSD17B1 | P14061 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
| ▸ | ATM | Q13315 | 1/20 | 0.30 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.30 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.30 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14721851 | 0.73 | TUBB4A (0.48) | — | |
| SCHEMBL14722143 | 0.71 | CCNB2 (0.43) | MEN1KMT2AMAPTMAPK1 | |
| SCHEMBL14722617 | 0.65 | KDM4E (0.36) | MEN1KMT2AHSD17B1MAPT | |
| SCHEMBL14725261 | 0.64 | TUBB4A (0.49) | MEN1KMT2AMAPTMAPK1 | |
| SCHEMBL16528083 | 0.64 | HSD17B1 (0.50) | MEN1KMT2AHSD17B1MAPT | |
| SCHEMBL14721210 | 0.64 | KDM4E (0.37) | MEN1KMT2AMAPTLTB4R | |
| SCHEMBL14722671 | 0.63 | PDGFRB (0.43) | MEN1KMT2AMAPT | |
| SCHEMBL2045876 | 0.61 | POLB (0.64) | KMT2AHSP90AA1MAPTMAPK1L3MBTL1 | |
| SCHEMBL14725538 | 0.61 | KDM4E (0.39) | MEN1KMT2AMAPT | |
| SCHEMBL25329818 | 0.61 | CYP3A4 (0.41) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013026942-A1 | TUBULIN BINDING AGENTS | THE PROVOST, FELLOWS, FOUNDATION SCHOLARS, AND THE OTHER MEMBERS OF BOARD, OF THE COLLEGE OF THE HOLY AND UNDIVIDED TRINITY OF QUEEN ELIZABETH, NEAR DUBLIN (IE) | 2013-02-28 | — | — | WO | disclosed |