Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 7/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.36 |
| ▸ | NPC1 | O15118 | 5/20 | 0.36 |
| ▸ | RAB9A | P51151 | 5/20 | 0.36 |
| ▸ | TP53 | P04637 | 2/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 3/20 | 0.35 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.35 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.35 |
| ▸ | RELA | Q04206 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.34 |
| ▸ | HTR3A | P46098 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8858892 | 0.82 | GRM5 (0.36) | GRM5ALDH1A1KDM4ENPC1RAB9A | |
| SCHEMBL13153126 | 0.77 | GRM5 (0.54) | GRM5ALDH1A1KDM4ENPC1RAB9A | |
| SCHEMBL15754794 | 0.74 | GRM5 (0.55) | GRM5ALDH1A1KDM4ENPC1RAB9A | |
| SCHEMBL18472057 | 0.71 | GRM5 (0.49) | GRM5ALDH1A1KDM4ENPC1RAB9A | |
| SCHEMBL4562282 | 0.70 | KDM4E (0.34) | ALDH1A1KDM4ERAB9ANPSR1HPGD | |
| SCHEMBL13155401 | 0.68 | L3MBTL1 (0.42) | MEN1KMT2A | |
| SCHEMBL10143645 | 0.66 | PDE10A (0.38) | GRM5ALDH1A1KDM4ENPC1RAB9A | |
| SCHEMBL3971488 | 0.66 | NPC1 (0.61) | GRM5ALDH1A1KDM4ENPC1RAB9A | |
| SCHEMBL27122183 | 0.66 | GRM5 (0.34) | GRM5ALDH1A1KDM4ENPC1RAB9A | |
| SCHEMBL15760264 | 0.64 | OPRM1 (0.42) | GRM5CHRNA7HTR3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9073927-B2 | Inhibitors of PI3 kinase | FUNDACION CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III (ES) | 2015-07-07 | — | — | US | disclosed |
| US-20130131057-A1 | NEW BICYCLIC COMPOUNDS AS PI3-K AND MTOR INHIBITORS | CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS (CNIO (ES) | 2013-05-23 | — | — | US | disclosed |
| US-20130053371-A1 | INHIBITORS OF PI3 KINASE | CENTRO NACIONAL DE INVESTIGACIONES ONCOLÓGICAS (CNIO) (ES) | 2013-02-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130053371-A1 | INHIBITORS OF PI3 KINASE | PIK3CA, MTOR, PIK3C2A | GRM5 4563/4885ALDH1A1 2425/4885KDM4E 2475/4885 |
| US-20130131057-A1 | NEW BICYCLIC COMPOUNDS AS PI3-K AND MTOR INHIBITORS | MTOR, PIK3CA, PIK3C2A | GRM5 4592/4885ALDH1A1 3580/4885KDM4E 2214/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.