Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMPD1 | P17405 | 2/20 | 0.64 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.64 |
| ▸ | PPP1CA | P62136 | 1/20 | 0.64 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.63 |
| ▸ | CA9 | Q16790 | 1/20 | 0.62 |
| ▸ | RPA1 | P27694 | 3/20 | 0.57 |
| ▸ | MALT1 | Q9UDY8 | 3/20 | 0.54 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.54 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.54 |
| ▸ | RELA | Q04206 | 1/20 | 0.54 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.53 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL877377 | 0.94 | SMPD1 (0.58) | SMPD1SMN1; SMN2PPP1CAPTGS2CA9 | |
| SCHEMBL3866686 | 0.91 | SMPD1 (0.56) | SMPD1SMN1; SMN2PPP1CAPTGS2CA9 | |
| SCHEMBL16797379 | 0.90 | KDM1A (0.60) | SMPD1SMN1; SMN2PPP1CAPTGS2CA9 | |
| SCHEMBL861458 | 0.90 | SMPD1 (0.55) | SMPD1SMN1; SMN2PPP1CAPTGS2CA9 | |
| SCHEMBL3863977 | 0.90 | PTGS2 (0.66) | SMPD1SMN1; SMN2PPP1CAPTGS2CA9 | |
| SCHEMBL13290381 | 0.90 | PTGS2 (0.66) | SMPD1SMN1; SMN2PPP1CAPTGS2CA9 | |
| SCHEMBL14728144 | 0.89 | SMPD1 (0.54) | SMPD1SMN1; SMN2PPP1CAPTGS2CA9 | |
| SCHEMBL3874092 | 0.89 | PTGS2 (0.82) | SMN1; SMN2PTGS2CA9MAPK9CHRNA7 | |
| SCHEMBL8369157 | 0.89 | RPA1 (0.65) | SMPD1SMN1; SMN2PPP1CAPTGS2CA9 | |
| SCHEMBL861050 | 0.88 | SMPD1 (0.53) | SMPD1SMN1; SMN2PPP1CAPTGS2CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8865130-B2 | Methods and compositions for diagnostic and therapeutic targeting of COX-2 | VANDERBILT UNIVERSITY (US) | 2014-10-21 | — | — | US | disclosed |
| US-20130052138-A1 | METHODS AND COMPOSITIONS FOR DIAGNOSTIC AND THERAPEUTIC TARGETING OF COX-2 | VANDERBILT UNIVERSITY (US) | 2013-02-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130052138-A1 | METHODS AND COMPOSITIONS FOR DIAGNOSTIC AND THERAPEUTIC TARGETING OF COX-2 | PTGS2, PTGES2, PTGER2 | SMPD1 677/4885SMN1; SMN2 1445/4885PPP1CA 4317/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.