Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 4/20 | 0.35 |
| ▸ | CXCR3 | P49682 | 7/20 | 0.34 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.34 |
| ▸ | DGAT1 | O75907 | 3/20 | 0.34 |
| ▸ | RET | P07949 | 1/20 | 0.33 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.32 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14729071 | 0.96 | GPR119 (0.39) | GPR119CXCR3HRH3DGAT1RET | |
| SCHEMBL14729187 | 0.92 | GPR119 (0.35) | GPR119CXCR3HRH3DGAT1ADORA2A | |
| SCHEMBL14729066 | 0.87 | GPR119 (0.39) | GPR119CXCR3HRH3DGAT1ADORA2A | |
| SCHEMBL14729182 | 0.86 | GPR119 (0.40) | GPR119 | |
| SCHEMBL14729190 | 0.85 | GPR119 (0.39) | GPR119CXCR3HRH3DGAT1SCN9A | |
| SCHEMBL14729060 | 0.84 | GPR119 (0.39) | GPR119KCNH2 | |
| SCHEMBL14729186 | 0.82 | GPR119 (0.40) | GPR119CXCR3HRH3DGAT1 | |
| SCHEMBL14729175 | 0.82 | GPR119 (0.42) | GPR119HRH3 | |
| SCHEMBL14729183 | 0.81 | GPR119 (0.40) | GPR119 | |
| SCHEMBL14729070 | 0.81 | GPR119 (0.44) | GPR119CXCR3HRH3SCN9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8940716-B2 | Bicyclic heteroaryl compounds as GPR119 modulators | BRISTOL-MYERS SQUIBB COMPANY (US) | 2015-01-27 | — | — | US | disclosed |
| US-20130053345-A1 | BICYCLIC HETEROARLY ANALOGUES AS GPR119 MODULATORS | BRISTOL-MYERS SQUIBB COMPANY | 2013-02-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130053345-A1 | BICYCLIC HETEROARLY ANALOGUES AS GPR119 MODULATORS | GPR119, GPR139, GPR4 | GPR119 1/4885CXCR3 616/4885HRH3 522/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.