SCHEMBL14729303

SCHEMBL14729303

CC(C)(C)OC(=O)CC[C@H](NC(=O)C[C@H](NC(=O)CCCN=[N+]=[N-])C(=O)OC(C)(C)C)C(=O)OC(C)(C)C

nearest known ligand 0.41

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
▸ KMT2A Q03164 2/20 0.41
▸ POLB P06746 1/20 0.41
▸ HDAC8 Q9BY41 1/20 0.36
▸ L3MBTL1 Q9Y468 1/20 0.35
▸ CNR1 P21554 1/20 0.31
▸ CNR2 P34972 1/20 0.31
▸ TDP1 Q9NUW8 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18145473 1.00 KMT2A (0.41) KMT2APOLBHDAC8L3MBTL1CNR1
SCHEMBL18161562 1.00 KMT2A (0.41) KMT2APOLBHDAC8L3MBTL1CNR1
SCHEMBL18145848 0.89 L3MBTL1 (0.36) KMT2APOLBHDAC8L3MBTL1
SCHEMBL14729276 0.89 L3MBTL1 (0.36) KMT2APOLBHDAC8L3MBTL1
SCHEMBL22733317 0.88 KMT2A (0.34) KMT2APOLBHDAC8L3MBTL1
SCHEMBL24630327 0.86 KMT2A (0.38) KMT2APOLBHDAC8CNR1CNR2
SCHEMBL22733296 0.83 L3MBTL1 (0.34) KMT2APOLBHDAC8L3MBTL1
SCHEMBL25132707 0.83 KMT2A (0.41) KMT2APOLBHDAC8CNR1CNR2
SCHEMBL21541230 0.83 FOLH1 (0.38) KMT2APOLBHDAC8L3MBTL1TDP1
SCHEMBL16094006 0.83 FOLH1 (0.38) KMT2APOLBHDAC8L3MBTL1TDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12583887-B2 PSMA imaging agents SIEMENS MEDICAL SOLUTIONS USA, INC. (US) 2026-03-24 — — US disclosed
US-12559521-B2 PSMA imaging agents SIEMENS MEDICAL SOLUTIONS USA, INC. (US) 2026-02-24 — — US disclosed
US-20240425547-A1 PSMA Imaging Agents SIEMENS MEDICAL SOLUTIONS USA, INC. 2024-12-26 — — US disclosed
US-20240409580-A1 PSMA Imaging Agents SIEMENS MEDICAL SOLUTIONS USA, INC. 2024-12-12 — — US disclosed
US-12139554-B2 PSMA imaging agents SIEMENS MEDICAL SOLUTIONS USA, INC. (US) 2024-11-12 — — US disclosed
US-12122851-B2 PSMA imaging agents SIEMENS MEDICAL SOLUTIONS USA, INC. (US) 2024-10-22 — — US disclosed
US-20210032286-A1 PSMA Imaging Agents SIEMENS MEDICAL SOLUTIONS USA, INC. 2021-02-04 — — US disclosed
US-20210024574-A1 PSMA Imaging Agents SIEMENS MEDICAL SOLUTIONS USA, INC. 2021-01-28 — — US disclosed
US-10894807-B2 PSMA imaging agents SIEMENS MEDICAL SOLUTIONS USA, INC. (US) 2021-01-19 — — US disclosed
US-10894807-B2 PSMA imaging agents SIEMENS MEDICAL SOLUTIONS USA, INC. (US) 2021-01-19 — — US disclosed
US-20200377549-A1 PSMA Imaging Agents SIEMENS MEDICAL SOLUTIONS USA, INC. 2020-12-03 — — US disclosed
US-20180258134-A1 PSMA Imaging Agents SIEMENS MEDICAL SOLUTIONS USA, INC. 2018-09-13 — — US disclosed
US-10011632-B2 PSMA imaging agents SIEMENS MEDICAL SOLUTIONS USA, INC. (US) 2018-07-03 — — US disclosed
US-10011632-B2 PSMA imaging agents SIEMENS MEDICAL SOLUTIONS USA, INC. (US) 2018-07-03 — — US disclosed
US-10011632-B2 PSMA imaging agents SIEMENS MEDICAL SOLUTIONS USA, INC. (US) 2018-07-03 — — US disclosed
US-20160304555-A1 PSMA Imaging Agents SIEMENS MEDICAL SOLUTIONS USA, INC. 2016-10-20 — — US disclosed
US-20160304555-A1 PSMA Imaging Agents SIEMENS MEDICAL SOLUTIONS USA, INC. 2016-10-20 — — US disclosed
US-20160304555-A1 PSMA Imaging Agents SIEMENS MEDICAL SOLUTIONS USA, INC. 2016-10-20 — — US disclosed
WO-2013028664-A1 PSMA IMAGING AGENTS SIEMENS MEDICAL SOLUTIONS USA, INC. (US) 2013-02-28 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (13 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240425547-A1 PSMA Imaging Agents FOLH1, KLK3, PSMA2 KMT2A 3251/4885POLB 3330/4885HDAC8 1913/4885
US-10894807-B2 PSMA imaging agents FOLH1, KLK3, PSMA2 KMT2A 3251/4885POLB 3330/4885HDAC8 1913/4885
US-20180258134-A1 PSMA Imaging Agents FOLH1, KLK3, PSMA2 KMT2A 3251/4885POLB 3330/4885HDAC8 1913/4885
US-20240409580-A1 PSMA Imaging Agents FOLH1, KLK3, PSMA2 KMT2A 3251/4885POLB 3330/4885HDAC8 1913/4885
US-12559521-B2 PSMA imaging agents KLK3, PSMA1, PSMA6 KMT2A 2592/4885POLB 3769/4885HDAC8 1259/4885
US-12139554-B2 PSMA imaging agents FOLH1, KLK3, PSMA2 KMT2A 3251/4885POLB 3330/4885HDAC8 1913/4885
US-20200377549-A1 PSMA Imaging Agents FOLH1, KLK3, PSMA2 KMT2A 3251/4885POLB 3330/4885HDAC8 1913/4885
US-12583887-B2 PSMA imaging agents KLK3, PSMA3, PSMA1 KMT2A 2897/4885POLB 3904/4885HDAC8 1440/4885
US-20210032286-A1 PSMA Imaging Agents FOLH1, KLK3, PSMA2 KMT2A 3251/4885POLB 3330/4885HDAC8 1913/4885
US-10011632-B2 PSMA imaging agents FOLH1, KLK3, PSMA2 KMT2A 3251/4885POLB 3330/4885HDAC8 1913/4885
US-12122851-B2 PSMA imaging agents FOLH1, KLK3, PSMA2 KMT2A 3251/4885POLB 3330/4885HDAC8 1913/4885
US-20210024574-A1 PSMA Imaging Agents FOLH1, KLK3, PSMA2 KMT2A 3251/4885POLB 3330/4885HDAC8 1913/4885
US-20160304555-A1 PSMA Imaging Agents FOLH1, KLK3, PSMA2 KMT2A 3251/4885POLB 3330/4885HDAC8 1913/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

Send feedback