Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 3/20 | 0.34 |
| ▸ | VNN1 | O95497 | 1/20 | 0.34 |
| ▸ | NR1H2 | P55055 | 3/20 | 0.33 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.33 |
| ▸ | BRAF | P15056 | 2/20 | 0.33 |
| ▸ | EIF2AK4 | Q9P2K8 | 1/20 | 0.32 |
| ▸ | CCR5 | P51681 | 1/20 | 0.32 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.32 |
| ▸ | KDM4D | Q6B0I6 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.31 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.31 |
| ▸ | HTR2A | P28223 | 1/20 | 0.31 |
| ▸ | DRD3 | P35462 | 1/20 | 0.31 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | CYP46A1 | Q9Y6A2 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14730202 | 0.91 | NTRK1 (0.35) | NTRK1VNN1NR1H2NR1H3BRAF | |
| SCHEMBL14730252 | 0.90 | GPR119 (0.37) | NTRK1VNN1NR1H2NR1H3BRAF | |
| SCHEMBL14730312 | 0.90 | GPR119 (0.36) | NTRK1VNN1NR1H2NR1H3BRAF | |
| SCHEMBL14730327 | 0.90 | GPR119 (0.35) | NR1H2NR1H3EIF2AK4MAPTGPR119 | |
| SCHEMBL14730167 | 0.89 | GPR119 (0.37) | NR1H2NR1H3GPR119 | |
| SCHEMBL14730173 | 0.87 | PDK2 (0.34) | NR1H2NR1H3BRAFEIF2AK4CCR5 | |
| SCHEMBL14730207 | 0.87 | NTRK1 (0.34) | NTRK1VNN1NR1H2NR1H3BRAF | |
| SCHEMBL14730206 | 0.87 | GPR119 (0.36) | NR1H2NR1H3GPR119 | |
| SCHEMBL14730325 | 0.86 | NTRK1 (0.33) | NTRK1NR1H2NR1H3EIF2AK4CCR5 | |
| SCHEMBL14730216 | 0.86 | GPR119 (0.33) | NTRK1VNN1NR1H2NR1H3BRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013026587-A1 | 1,4 DISUBSTITUTED PYRROLIDINE - 3 - YL -AMINE DERIVATIVES AND THEIR USE FOR THE TREATMENT OF METABOLIC DISORDERS | PROSIDION LIMITED (GB) | 2013-02-28 | — | — | WO | disclosed |