Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 4/20 | 0.37 |
| ▸ | NTRK1 | P04629 | 3/20 | 0.35 |
| ▸ | VNN1 | O95497 | 1/20 | 0.34 |
| ▸ | ACKR3 | P25106 | 2/20 | 0.33 |
| ▸ | NR1H2 | P55055 | 3/20 | 0.33 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.33 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.33 |
| ▸ | EIF2AK4 | Q9P2K8 | 1/20 | 0.33 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.32 |
| ▸ | BRAF | P15056 | 1/20 | 0.32 |
| ▸ | SYK | P43405 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14730202 | 0.95 | NTRK1 (0.35) | GPR119NTRK1VNN1ACKR3NR1H2 | |
| SCHEMBL14730256 | 0.91 | PDK2 (0.34) | GPR119NTRK1VNN1ACKR3NR1H2 | |
| SCHEMBL14730312 | 0.91 | GPR119 (0.36) | GPR119NTRK1VNN1ACKR3NR1H2 | |
| SCHEMBL14730205 | 0.90 | NTRK1 (0.34) | GPR119NTRK1VNN1ACKR3NR1H2 | |
| SCHEMBL14730216 | 0.90 | GPR119 (0.33) | GPR119NTRK1VNN1ACKR3NR1H2 | |
| SCHEMBL14730318 | 0.89 | NTRK1 (0.34) | GPR119NTRK1ACKR3NR1H2NR1H3 | |
| SCHEMBL14730207 | 0.88 | NTRK1 (0.34) | NTRK1VNN1ACKR3NR1H2NR1H3 | |
| SCHEMBL14730212 | 0.88 | NTRK1 (0.33) | GPR119NTRK1ACKR3NR1H2NR1H3 | |
| SCHEMBL14730275 | 0.88 | NTRK1 (0.34) | GPR119NTRK1ACKR3NR1H2NR1H3 | |
| SCHEMBL14730263 | 0.86 | GPR119 (0.35) | GPR119NTRK1VNN1NR1H2NR1H3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013026587-A1 | 1,4 DISUBSTITUTED PYRROLIDINE - 3 - YL -AMINE DERIVATIVES AND THEIR USE FOR THE TREATMENT OF METABOLIC DISORDERS | PROSIDION LIMITED (GB) | 2013-02-28 | — | — | WO | disclosed |