Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 5/20 | 0.34 |
| ▸ | VNN1 | O95497 | 3/20 | 0.32 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.31 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.31 |
| ▸ | HTR2A | P28223 | 1/20 | 0.31 |
| ▸ | DRD3 | P35462 | 1/20 | 0.31 |
| ▸ | EIF2AK4 | Q9P2K8 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | WDR5 | P61964 | 1/20 | 0.31 |
| ▸ | F2R | P25116 | 1/20 | 0.31 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.30 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.30 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.30 |
| ▸ | BRAF | P15056 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14730312 | 0.91 | GPR119 (0.36) | NTRK1VNN1HDAC4HDAC6HTR2A | |
| SCHEMBL14730202 | 0.88 | NTRK1 (0.35) | NTRK1VNN1HDAC4HDAC6EIF2AK4 | |
| SCHEMBL14730255 | 0.88 | PDK2 (0.34) | — | |
| SCHEMBL14730252 | 0.88 | GPR119 (0.37) | NTRK1VNN1HDAC4HDAC6EIF2AK4 | |
| SCHEMBL14730205 | 0.87 | NTRK1 (0.34) | NTRK1VNN1HDAC4HDAC6HTR2A | |
| SCHEMBL14730263 | 0.87 | GPR119 (0.35) | NTRK1VNN1HDAC4HDAC6EIF2AK4 | |
| SCHEMBL14730289 | 0.86 | MCHR1 (0.34) | NTRK1VNN1HTR2ADRD3MEN1 | |
| SCHEMBL14730179 | 0.85 | GPR119 (0.34) | NTRK1HTR2ADRD3NR1H2 | |
| SCHEMBL14730276 | 0.85 | — | — | |
| SCHEMBL14730227 | 0.84 | NTRK1 (0.34) | NTRK1HTR2ADRD3NR1H2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013026587-A1 | 1,4 DISUBSTITUTED PYRROLIDINE - 3 - YL -AMINE DERIVATIVES AND THEIR USE FOR THE TREATMENT OF METABOLIC DISORDERS | PROSIDION LIMITED (GB) | 2013-02-28 | — | — | WO | disclosed |