Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.35 |
| ▸ | PDK2 | Q15119 | 2/20 | 0.34 |
| ▸ | SYK | P43405 | 2/20 | 0.32 |
| ▸ | EIF2AK4 | Q9P2K8 | 1/20 | 0.32 |
| ▸ | NR1H2 | P55055 | 3/20 | 0.31 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.31 |
| ▸ | BRAF | P15056 | 2/20 | 0.31 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.31 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.31 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.31 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.31 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.31 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.31 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.31 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.31 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.31 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.31 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.31 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.31 |
| ▸ | VNN1 | O95497 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14730312 | 0.95 | GPR119 (0.36) | GPR119EIF2AK4NR1H2NR1H3BRAF | |
| SCHEMBL14730219 | 0.92 | PDK2 (0.36) | GPR119PDK2SYKEIF2AK4NR1H2 | |
| SCHEMBL14730216 | 0.92 | GPR119 (0.33) | GPR119PDK2SYKEIF2AK4NR1H2 | |
| SCHEMBL14730256 | 0.91 | PDK2 (0.34) | GPR119PDK2SYKEIF2AK4NR1H2 | |
| SCHEMBL14730327 | 0.91 | GPR119 (0.35) | GPR119PDK2SYKEIF2AK4NR1H2 | |
| SCHEMBL14730175 | 0.91 | SYK (0.32) | PDK2SYKEIF2AK4NR1H2NR1H3 | |
| SCHEMBL14730202 | 0.87 | NTRK1 (0.35) | GPR119EIF2AK4NR1H2NR1H3BRAF | |
| SCHEMBL14730207 | 0.87 | NTRK1 (0.34) | EIF2AK4NR1H2NR1H3BRAFHDAC4 | |
| SCHEMBL14730252 | 0.86 | GPR119 (0.37) | GPR119SYKEIF2AK4NR1H2NR1H3 | |
| SCHEMBL14730179 | 0.86 | GPR119 (0.34) | GPR119NR1H2NTRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013026587-A1 | 1,4 DISUBSTITUTED PYRROLIDINE - 3 - YL -AMINE DERIVATIVES AND THEIR USE FOR THE TREATMENT OF METABOLIC DISORDERS | PROSIDION LIMITED (GB) | 2013-02-28 | — | — | WO | disclosed |