SCHEMBL14730405

SCHEMBL14730405

CN/C=N/c1nc(O/N=C(\C)c2ccccc2)ncc1F

nearest known ligand 0.45

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
LMNA P02545 1/20 0.34
MAPK1 P28482 1/20 0.34
HTT P42858 1/20 0.34
L3MBTL1 Q9Y468 1/20 0.34
HPGD P15428 1/20 0.32
PPARG P37231 1/20 0.30
PPARA Q07869 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13530029 0.84 ALDH1A1 (0.37) LMNAMAPK1HTTL3MBTL1HPGD
SCHEMBL16303087 0.84 ALDH1A1 (0.37) LMNAMAPK1HTTL3MBTL1HPGD
SCHEMBL3174553 0.77 LMNA (0.40) LMNAMAPK1HTTL3MBTL1HPGD
SCHEMBL3174547 0.77 LMNA (0.40) LMNAMAPK1HTTL3MBTL1HPGD
SCHEMBL16303089 0.76 EGFR (0.36) LMNAMAPK1HTTL3MBTL1HPGD
SCHEMBL13530303 0.74 EGFR (0.38) LMNAMAPK1HTTL3MBTL1HPGD
SCHEMBL14733453 0.70 ALDH1A1 (0.35) LMNAMAPK1HTTL3MBTL1HPGD
SCHEMBL15661736 0.69 LMNA (0.55) LMNAMAPK1HTTL3MBTL1HPGD
SCHEMBL15661735 0.69 LMNA (0.55) LMNAMAPK1HTTL3MBTL1HPGD
SCHEMBL15661733 0.69 LMNA (0.55) LMNAMAPK1HTTL3MBTL1HPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2562167-A1 5-FLUORO PYRIMIDINE DERIVATIVES AS FUNGICIDES Dow AgroSciences LLC (US) 2013-02-27 EP disclosed
EP-2562164-A1 5-FLUORO PYRIMIDINE DERIVATIVES AS FUNGICIDES Dow AgroSciences LLC (US) 2013-02-27 EP disclosed