Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA9 | Q16790 | 13/20 | 0.68 |
| ▸ | CA1 | P00915 | 12/20 | 0.68 |
| ▸ | CA2 | P00918 | 12/20 | 0.68 |
| ▸ | PTGS2 | P35354 | 4/20 | 0.64 |
| ▸ | CNR1 | P21554 | 1/20 | 0.53 |
| ▸ | CNR2 | P34972 | 1/20 | 0.53 |
| ▸ | RPA1 | P27694 | 1/20 | 0.52 |
| ▸ | FAAH | O00519 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13239860 | 0.91 | CA1 (0.70) | CA9CA1CA2PTGS2CNR1 | |
| SCHEMBL6344401 | 0.81 | CA9 (1.00) | CA9CA1CA2PTGS2 | |
| SCHEMBL12285042 | 0.81 | PTGS2 (0.70) | CA9CA1CA2PTGS2CNR1 | |
| SCHEMBL13352312 | 0.81 | CA1 (0.60) | CA9CA1CA2PTGS2CNR1 | |
| Sulfamide SCHEMBL7182772 | 0.80 | PTGS2 (0.76) | CA9CA1CA2PTGS2 | |
| SCHEMBL8689665 | 0.79 | CA9 (1.00) | CA9CA1CA2PTGS2 | |
| SCHEMBL3864236 | 0.79 | PTGS2 (0.90) | CA9CA1CA2PTGS2 | |
| SCHEMBL9941289 | 0.79 | PTGS2 (1.00) | CA9CA1CA2PTGS2 | |
| SCHEMBL3865949 | 0.78 | PTGS2 (0.58) | CA9CA1CA2PTGS2CNR1 | |
| SCHEMBL27710506 | 0.77 | CNR1 (0.53) | CA9CA1CA2PTGS2CNR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE44048-E1 | 4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-YL]benzenesulfonamide for the treatment of inflammation or an inflammation-associated disorder | G.D. SEARLE LLC (US) | 2013-03-05 | — | — | US | disclosed |