SCHEMBL14733367

SCHEMBL14733367

O=C(Nc1ncnc2c1ncn2[C@H]1C[C@@H](O)[C@@H](CO)O1)c1ccccc1

nearest known ligand 0.65

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
SLC29A1 Q99808 1/20 0.59
HIF1A Q16665 1/20 0.57

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29674600 1.00 SLC29A1 (0.59) SLC29A1HIF1A
SCHEMBL21539907 1.00 SLC29A1 (0.59) SLC29A1HIF1A
SCHEMBL264409 1.00 SLC29A1 (0.59) SLC29A1HIF1A
SCHEMBL22984010 1.00 SLC29A1 (0.59) SLC29A1HIF1A
SCHEMBL264408 1.00 SLC29A1 (0.59) SLC29A1HIF1A
Water SCHEMBL29821265 0.99 SLC29A1 (0.58) SLC29A1HIF1A
SCHEMBL23881920 0.92 SLC29A1 (0.49) SLC29A1HIF1A
SCHEMBL31093228 0.92 SLC29A1 (0.49) SLC29A1
SCHEMBL9342970 0.92 SLC29A1 (0.49) SLC29A1HIF1A
SCHEMBL9342988 0.92 SLC29A1 (0.49) SLC29A1HIF1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10597421-B2 Protected monomer and method of final deprotection for RNA synthesis AGILENT TECHNOLOGIES, INC. (US) 2020-03-24 US disclosed
US-20180186826-A1 PROTECTED MONOMER AND METHOD OF FINAL DEPROTECTION FOR RNA SYNTHESIS AGILENT TECHNOLOGIES, INC. 2018-07-05 US disclosed
WO-2017160741-A1 COMPOSITIONS AND METHODS FOR PHOSPHORAMIDITE AND OLIGONUCLEOTIDE SYNTHESIS WAVE LIFE SCIENCES LTD. (SG) 2017-09-21 WO disclosed
US-20140163037-A1 SCREENING METHODS FOR IDENTIFYING SPECIFIC STAPHYLOCOCCUS AUREUS INHIBITORS TRANA DISCOVERY, INC. (US) 2014-06-12 US disclosed
US-20130053258-A1 COMBINATORIAL LIBRARY, A METHOD FOR PREPARATION OF THAT COMBINATORIAL LIBRARY, A METHOD FOR SEQUENCE IDENTIFICATION, A METHOD FOR SEQUENCING THE ELEMENTS OF COMBINATORIAL LIBRARIES OF OLIGONUCLEOTIDES AND/OR OLIGONUCLEOTIDE ANALOGUES, THE USE OF A LINKER TO GENERATE COMBINATORIAL LIBRARIES AND A SEQUENCE IDENTIFICATION SET INSTYTUT CHEMII BIOORGANICZNEJ PAN (PL) 2013-02-28 US disclosed
US-20110009607-A1 METHOD FOR PREPARING DNA FRAGMENT HAVING STICKY END THE UNIVERSITY OF TOKYO (JP) 2011-01-13 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20140163037-A1 SCREENING METHODS FOR IDENTIFYING SPECIFIC STAPHYLOCOCCUS AUREUS INHIBITORS NSUN3, RNGTT, TRMT1 SLC29A1 525/4885HIF1A 4276/4885
US-20180186826-A1 PROTECTED MONOMER AND METHOD OF FINAL DEPROTECTION FOR RNA SYNTHESIS NSUN2, RNGTT, RNMT SLC29A1 1026/4885HIF1A 3291/4885
US-10597421-B2 Protected monomer and method of final deprotection for RNA synthesis NSUN2, RNGTT, RNMT SLC29A1 1026/4885HIF1A 3291/4885
US-20110009607-A1 METHOD FOR PREPARING DNA FRAGMENT HAVING STICKY END POLB, POLL, POLN SLC29A1 3265/4885HIF1A 3185/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.